In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi

J. S. De Araújo, C. F. Da Silva, D. G.J. Batista, P. B. Da Silva, M. B. Meuser, C. A.F. Aiub, M. F.V. Da Silva, C. F. Araújo-Lima, M. Banerjee, A. A. Farahat, C. E. Stephens, A. Kumar, D. W. Boykin, M. N.C. Soeiro

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5 Scopus citations

Abstract

Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.

Original languageEnglish (US)
Pages (from-to)4191-4195
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number7
DOIs
StatePublished - Jul 2014

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

De Araújo, J. S., Da Silva, C. F., Batista, D. G. J., Da Silva, P. B., Meuser, M. B., Aiub, C. A. F., Da Silva, M. F. V., Araújo-Lima, C. F., Banerjee, M., Farahat, A. A., Stephens, C. E., Kumar, A., Boykin, D. W., & Soeiro, M. N. C. (2014). In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi. Antimicrobial agents and chemotherapy, 58(7), 4191-4195. https://doi.org/10.1128/AAC.01403-13