In vitro cytotoxicity against human cancer cell lines during pulsed magnetic field exposure

C. J. Hannan, Y. Liang, Jerry David Allison, J. R. Searle

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

In an in vitro cell growth assay carboplatin potency against A-431 cells increased after a 1 hour PMF (pulsed magnetic field) exposure (calculated peak field 5.2 in Tesla with an average field strength of 0.525 mTesla(rms); pulses rose for 120 μsec and then abruptly fell to neutral and were repeated at a rate of 100 or 250 pulses per second). This potentiating effect was not observed with cisplatin or daunomycin. When cytotoxicity against HT-29 cells was measured PMF exposure potentiated both carboplatin and daunomycin but again not cisplatin. Both cell types exhibited increased growth when exposed only to PMF. Exposure to PMF consistently increased the cell growth of these cancer cell lines while only some in vitro antineoplastic agents were potentiated by PMFs.

Original languageEnglish (US)
Pages (from-to)1517-1520
Number of pages4
JournalAnticancer research
Volume14
Issue number4 A
StatePublished - 1994

Keywords

  • Carboplatin
  • Chemotherapy
  • Cisplatin
  • Daunorubicin
  • Experimental therapeutics
  • Pulsed magnetic field

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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