In vitro evidence for the protective role of sida rhomboidea. Roxb extract against LDL oxidation and oxidized ldl-induced apoptosis in human monocyte-derived macrophages

Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Ranjisinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.

Original languageEnglish (US)
Pages (from-to)168-179
Number of pages12
JournalCardiovascular Toxicology
Volume11
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • Atheorsclerosis
  • LDL oxidation
  • Macrophage apoptosis
  • Oxidative stress
  • S. rhomboidea. Roxb

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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