In vitro study assessing the antibacterial activity of three silver-impregnated/coated mechanical valve needleless connectors after blood exposure

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This in vitro study's purpose was to assess antibacterial activity of 3 different connectors: V-Link (Baxter, Deerfield, IL), Ultrasite Ag (B. Braun, Bethlehem, PA), and MaxGuard (CareFusion, Ontario, CA), impregnated with silver nanoparticles after blood exposure. All 3 silver-coated/impregnated connectors grew Staphylococcus aureus and Staphylococcus epidermidis. Log reduction of bacteria was not significant (range, +0.19 to -1.82). There was substantial bacterial recovery from all 3 connectors (mean ranges, 2.09 × 10 7 to 4.00 × 108) indicating that, once blood comes in contact with silver-coated/impregnated needleless connectors, their antibacterial activity is significantly reduced.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalAmerican Journal of Infection Control
Issue number3
Publication statusPublished - Mar 1 2013



  • Bacteremia
  • Bloodstream infections
  • Central line-associated bloodstream infections
  • Intravenous

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Health Policy

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