In vitro susceptibilities of Candida and Aspergillus species to Melaleuca alternafolia (tea tree) oil

Jose Antonio Vazquez, M. T. Arganoza, D. Boikov, J. K. Vaishampayan, R. A. Akins

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Candida species are an important cause of opportunistic infection in the oral cavity of immunocompromised patients, especially HIV infected patients. Melaleuca oil obtained commercially was investigated since it is known to have broad antifungal properties. The in-vitro susceptibilities of Aspergillus and susceptible and resistant Candida species were performed utilizing serial dilutions in microtiter plates with Sabouraud dextrose agar and the commercial preparation of Melaleuca. As a comparator, in vitro susceptibilities to amphotericin B and fluconazole were also determined using the broth microdilution technique. The results demonstrate that Melaleuca inhibited the Candida species. However, the growth of Aspergillus was not inhibited at the concentrations tested. Thus, preparations containing Melaleuca alternafolia may be a useful alternative for superficial candidal infections. In fact, it may be a useful alternative regimen for advanced HIV-positive patients with oropharyngeal candidiasis refractory to fluconazole. However, controlled clinical studies to evaluate its efficacy are still needed.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalRevista Iberoamericana de Micologia
Volume17
Issue number2
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Melaleuca
Tea Tree Oil
Aspergillus
Candida
Fluconazole
HIV
Candidiasis
Opportunistic Infections
Immunocompromised Host
Amphotericin B
Agar
Mouth
Oils
Glucose
In Vitro Techniques
Growth
Infection

Keywords

  • Candida
  • In vitro susceptibility
  • Melaleuca alternafolia

ASJC Scopus subject areas

  • Microbiology

Cite this

In vitro susceptibilities of Candida and Aspergillus species to Melaleuca alternafolia (tea tree) oil. / Vazquez, Jose Antonio; Arganoza, M. T.; Boikov, D.; Vaishampayan, J. K.; Akins, R. A.

In: Revista Iberoamericana de Micologia, Vol. 17, No. 2, 01.01.2000, p. 60-63.

Research output: Contribution to journalArticle

Vazquez, Jose Antonio ; Arganoza, M. T. ; Boikov, D. ; Vaishampayan, J. K. ; Akins, R. A. / In vitro susceptibilities of Candida and Aspergillus species to Melaleuca alternafolia (tea tree) oil. In: Revista Iberoamericana de Micologia. 2000 ; Vol. 17, No. 2. pp. 60-63.
@article{3cce9fcce8d7474fadd9b9543f8d389f,
title = "In vitro susceptibilities of Candida and Aspergillus species to Melaleuca alternafolia (tea tree) oil",
abstract = "Candida species are an important cause of opportunistic infection in the oral cavity of immunocompromised patients, especially HIV infected patients. Melaleuca oil obtained commercially was investigated since it is known to have broad antifungal properties. The in-vitro susceptibilities of Aspergillus and susceptible and resistant Candida species were performed utilizing serial dilutions in microtiter plates with Sabouraud dextrose agar and the commercial preparation of Melaleuca. As a comparator, in vitro susceptibilities to amphotericin B and fluconazole were also determined using the broth microdilution technique. The results demonstrate that Melaleuca inhibited the Candida species. However, the growth of Aspergillus was not inhibited at the concentrations tested. Thus, preparations containing Melaleuca alternafolia may be a useful alternative for superficial candidal infections. In fact, it may be a useful alternative regimen for advanced HIV-positive patients with oropharyngeal candidiasis refractory to fluconazole. However, controlled clinical studies to evaluate its efficacy are still needed.",
keywords = "Candida, In vitro susceptibility, Melaleuca alternafolia",
author = "Vazquez, {Jose Antonio} and Arganoza, {M. T.} and D. Boikov and Vaishampayan, {J. K.} and Akins, {R. A.}",
year = "2000",
month = "1",
day = "1",
language = "English (US)",
volume = "17",
pages = "60--63",
journal = "Revista Iberoamericana de Micologia",
issn = "1130-1406",
publisher = "Asociacion Espanola de Micologia",
number = "2",

}

TY - JOUR

T1 - In vitro susceptibilities of Candida and Aspergillus species to Melaleuca alternafolia (tea tree) oil

AU - Vazquez, Jose Antonio

AU - Arganoza, M. T.

AU - Boikov, D.

AU - Vaishampayan, J. K.

AU - Akins, R. A.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Candida species are an important cause of opportunistic infection in the oral cavity of immunocompromised patients, especially HIV infected patients. Melaleuca oil obtained commercially was investigated since it is known to have broad antifungal properties. The in-vitro susceptibilities of Aspergillus and susceptible and resistant Candida species were performed utilizing serial dilutions in microtiter plates with Sabouraud dextrose agar and the commercial preparation of Melaleuca. As a comparator, in vitro susceptibilities to amphotericin B and fluconazole were also determined using the broth microdilution technique. The results demonstrate that Melaleuca inhibited the Candida species. However, the growth of Aspergillus was not inhibited at the concentrations tested. Thus, preparations containing Melaleuca alternafolia may be a useful alternative for superficial candidal infections. In fact, it may be a useful alternative regimen for advanced HIV-positive patients with oropharyngeal candidiasis refractory to fluconazole. However, controlled clinical studies to evaluate its efficacy are still needed.

AB - Candida species are an important cause of opportunistic infection in the oral cavity of immunocompromised patients, especially HIV infected patients. Melaleuca oil obtained commercially was investigated since it is known to have broad antifungal properties. The in-vitro susceptibilities of Aspergillus and susceptible and resistant Candida species were performed utilizing serial dilutions in microtiter plates with Sabouraud dextrose agar and the commercial preparation of Melaleuca. As a comparator, in vitro susceptibilities to amphotericin B and fluconazole were also determined using the broth microdilution technique. The results demonstrate that Melaleuca inhibited the Candida species. However, the growth of Aspergillus was not inhibited at the concentrations tested. Thus, preparations containing Melaleuca alternafolia may be a useful alternative for superficial candidal infections. In fact, it may be a useful alternative regimen for advanced HIV-positive patients with oropharyngeal candidiasis refractory to fluconazole. However, controlled clinical studies to evaluate its efficacy are still needed.

KW - Candida

KW - In vitro susceptibility

KW - Melaleuca alternafolia

UR - http://www.scopus.com/inward/record.url?scp=0033791503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033791503&partnerID=8YFLogxK

M3 - Article

C2 - 15813697

AN - SCOPUS:0033791503

VL - 17

SP - 60

EP - 63

JO - Revista Iberoamericana de Micologia

JF - Revista Iberoamericana de Micologia

SN - 1130-1406

IS - 2

ER -