In vivo measurement of bone manganese and association with manual dexterity: A pilot study

Ellen M. Wells; Yingzi Liu; Danelle Rolle-McFarland; Farshad Mostafaei; Wei Zheng; Linda H. Nie

doi:10.1016/j.envres.2017.09.016

In vivo measurement of bone manganese and association with manual dexterity: A pilot study

Ellen M. Wells, Yingzi Liu, Danelle Rolle-McFarland, Farshad Mostafaei, Wei Zheng, Linda H. Nie

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89 µg/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln(BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: β = −1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied.

Original language	English (US)
Pages (from-to)	35-38
Number of pages	4
Journal	Environmental Research
Volume	160
DOIs	https://doi.org/10.1016/j.envres.2017.09.016
State	Published - 2018
Externally published	Yes

Keywords

Biomarkers
Environmental exposure
In vivo neutron activation analysis (IVNAA)
Manganese
Motor skills

ASJC Scopus subject areas

Biochemistry
Environmental Science(all)

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10.1016/j.envres.2017.09.016

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@article{910d50ce70564ca19a0e57c2a59830b8,

title = "In vivo measurement of bone manganese and association with manual dexterity: A pilot study",

abstract = "We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89 µg/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln(BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: β = −1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied.",

keywords = "Biomarkers, Environmental exposure, In vivo neutron activation analysis (IVNAA), Manganese, Motor skills",

author = "Wells, {Ellen M.} and Yingzi Liu and Danelle Rolle-McFarland and Farshad Mostafaei and Wei Zheng and Nie, {Linda H.}",

note = "Funding Information: The authors wish to thank the volunteers who participated in this pilot study as well as Ulrike Dydak, James Schweitzer, and Sandy Snyder for their assistance. This project was funded by the National Institute of Occupational Health Sciences R21 grant OH010700-01 . Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

doi = "10.1016/j.envres.2017.09.016",

language = "English (US)",

volume = "160",

pages = "35--38",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - In vivo measurement of bone manganese and association with manual dexterity

T2 - A pilot study

AU - Wells, Ellen M.

AU - Liu, Yingzi

AU - Rolle-McFarland, Danelle

AU - Mostafaei, Farshad

AU - Zheng, Wei

AU - Nie, Linda H.

N1 - Funding Information: The authors wish to thank the volunteers who participated in this pilot study as well as Ulrike Dydak, James Schweitzer, and Sandy Snyder for their assistance. This project was funded by the National Institute of Occupational Health Sciences R21 grant OH010700-01 . Publisher Copyright: © 2017 Elsevier Inc.

PY - 2018

Y1 - 2018

N2 - We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89 µg/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln(BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: β = −1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied.

AB - We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89 µg/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln(BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: β = −1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied.

KW - Biomarkers

KW - Environmental exposure

KW - In vivo neutron activation analysis (IVNAA)

KW - Manganese

KW - Motor skills

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DO - 10.1016/j.envres.2017.09.016

M3 - Article

C2 - 28961467

AN - SCOPUS:85029800192

SN - 0013-9351

VL - 160

SP - 35

EP - 38

JO - Environmental Research

JF - Environmental Research

ER -

In vivo measurement of bone manganese and association with manual dexterity: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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