In vivo measurement of bone manganese and association with manual dexterity: A pilot study

Ellen M. Wells, Yingzi Liu, Danelle Rolle-McFarland, Farshad Mostafaei, Wei Zheng, Linda H. Nie

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89 µg/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln(BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: β = −1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalEnvironmental Research
Volume160
DOIs
StatePublished - 2018

Keywords

  • Biomarkers
  • Environmental exposure
  • In vivo neutron activation analysis (IVNAA)
  • Manganese
  • Motor skills

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

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