In vivo probe of central cholinergic systems

K. J. Meador, D. W. Loring, Gregory P Lee, H. S. Taylor, D. R. Hughes, D. S. Feldman

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Age-related cognitive impairments and dementia of Alzheimer type have been linked to alterations in the cholinergic system. In the present study, evoked potentials and neuropsychological testing were obtained in healthy subjects during neuropharmacological manipulations including: scopolamine (anticholinergic), scopolamine plus physostigmine (anticholinergic), scopolamine plus methylphenidate (adrenergic), and placebo. Scopolamine prolonged P3 latency and reduced spectral power of long latency evoked potentials without significantly alterating earlier components. Physostigmine partially reversed these effects, but methylphenidate did not. Motor speed was showed by scopolamine, but not by scopolamine plus methylphenidate. Cholinergic systems appear to be involved in generation or modulation of the P3 potential, possibly secondary to the cholinergic role in selective attention. Similar techniques may be useful as in vivo probes of central cholinergic function and thus as research and diagnostic aids in aging and disease.

Original languageEnglish (US)
JournalJournals of Gerontology
Volume43
Issue number6
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Aging

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    Meador, K. J., Loring, D. W., Lee, G. P., Taylor, H. S., Hughes, D. R., & Feldman, D. S. (1988). In vivo probe of central cholinergic systems. Journals of Gerontology, 43(6). https://doi.org/10.1093/geronj/43.6.M158