In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B

Elias K. Manavathu; Jessica L. Cutright; Pranatharthi H. Chandrasekar

doi:10.1128/AAC.49.1.428-430.2005

In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B

Elias K. Manavathu, Jessica L. Cutright, Pranatharthi H. Chandrasekar

Infectious Disease

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

Original language	English (US)
Pages (from-to)	428-430
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	1
DOIs	https://doi.org/10.1128/AAC.49.1.428-430.2005
State	Published - Jan 1 2005

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ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Manavathu, E. K., Cutright, J. L., & Chandrasekar, P. H. (2005). In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B. Antimicrobial agents and chemotherapy, 49(1), 428-430. https://doi.org/10.1128/AAC.49.1.428-430.2005

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10.1128/AAC.49.1.428-430.2005