In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B

Elias K. Manavathu, Jessica L. Cutright, Pranatharthi H. Chandrasekar

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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