TY - JOUR
T1 - In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B
AU - Manavathu, Elias K.
AU - Cutright, Jessica L.
AU - Chandrasekar, Pranatharthi H.
PY - 2005/1
Y1 - 2005/1
N2 - The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.
AB - The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.
UR - http://www.scopus.com/inward/record.url?scp=11244267504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11244267504&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.1.428-430.2005
DO - 10.1128/AAC.49.1.428-430.2005
M3 - Article
C2 - 15616327
AN - SCOPUS:11244267504
VL - 49
SP - 428
EP - 430
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -