In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B

Elias Kurian Manavathu, Jessica L. Cutright, Pranatharthi H. Chandrasekar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2005

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Aspergillus fumigatus
Amphotericin B
Pulmonary Aspergillosis
Lung
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B. / Manavathu, Elias Kurian; Cutright, Jessica L.; Chandrasekar, Pranatharthi H.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 1, 01.01.2005, p. 428-430.

Research output: Contribution to journalArticle

Manavathu, Elias Kurian ; Cutright, Jessica L. ; Chandrasekar, Pranatharthi H. / In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 1. pp. 428-430.
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