Abstract
The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 428-430 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 49 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2005 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B. / Manavathu, Elias Kurian; Cutright, Jessica L.; Chandrasekar, Pranatharthi H.
In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 1, 01.01.2005, p. 428-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B
AU - Manavathu, Elias Kurian
AU - Cutright, Jessica L.
AU - Chandrasekar, Pranatharthi H.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.
AB - The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.
UR - http://www.scopus.com/inward/record.url?scp=11244267504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11244267504&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.1.428-430.2005
DO - 10.1128/AAC.49.1.428-430.2005
M3 - Article
VL - 49
SP - 428
EP - 430
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -