Incidence of BK Virus and JC virus viruria in human immunodeficiency virus-infected and -uninfected subjects

Rhea-Beth Markowitz, Harry C. Thompson, Jane F. Mueller, Jeffrey A. Cohen, William S. Dynan

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

BK virus (BKV) and JC virus (JCV) are present within the renal system of most adults. Reactivation may be linked to immunodeficiency, since many of the extant virus strains have been isolated from urine or kidney tissue of patients who were receiving immunosuppressive therapy or who had disorders of the immune system. To more critically evaluate the relationship between immunodeficiency and viruria, urine samples from individuals infected with human immunodeficiency virus (HIV) with various degrees of immunodeficiency were screened for the presence of viral DNA. JCV viruria occurred in 24%–27% of immunocompetent control subjects and was not increased with immunodeficiency. By contrast, there were both qualitative and quantitative changes in BKV viruria in immunodeficient subjects. The incidence of BKV viruria was increased, and some immunodeficient subjects shed BKV at levels up to 3000 times greater than levels shed by any of the nonimmunodeficient controls. DNA sequence rearrangements in the viral regulatory region did not appear to be required for shedding of virus, although they were present in ∼20% of samples.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalJournal of Infectious Diseases
Volume167
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

BK Virus
JC Virus
HIV
Incidence
Urine
Virus Shedding
Kidney
Gene Rearrangement
Nucleic Acid Regulatory Sequences
Viral DNA
Immunosuppressive Agents
Immune System
Viruses

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Incidence of BK Virus and JC virus viruria in human immunodeficiency virus-infected and -uninfected subjects. / Markowitz, Rhea-Beth; Thompson, Harry C.; Mueller, Jane F.; Cohen, Jeffrey A.; Dynan, William S.

In: Journal of Infectious Diseases, Vol. 167, No. 1, 01.01.1993, p. 13-20.

Research output: Contribution to journalArticle

Markowitz, Rhea-Beth ; Thompson, Harry C. ; Mueller, Jane F. ; Cohen, Jeffrey A. ; Dynan, William S. / Incidence of BK Virus and JC virus viruria in human immunodeficiency virus-infected and -uninfected subjects. In: Journal of Infectious Diseases. 1993 ; Vol. 167, No. 1. pp. 13-20.
@article{ef0b8ae2157c46f6a356c3b1b3f44525,
title = "Incidence of BK Virus and JC virus viruria in human immunodeficiency virus-infected and -uninfected subjects",
abstract = "BK virus (BKV) and JC virus (JCV) are present within the renal system of most adults. Reactivation may be linked to immunodeficiency, since many of the extant virus strains have been isolated from urine or kidney tissue of patients who were receiving immunosuppressive therapy or who had disorders of the immune system. To more critically evaluate the relationship between immunodeficiency and viruria, urine samples from individuals infected with human immunodeficiency virus (HIV) with various degrees of immunodeficiency were screened for the presence of viral DNA. JCV viruria occurred in 24{\%}–27{\%} of immunocompetent control subjects and was not increased with immunodeficiency. By contrast, there were both qualitative and quantitative changes in BKV viruria in immunodeficient subjects. The incidence of BKV viruria was increased, and some immunodeficient subjects shed BKV at levels up to 3000 times greater than levels shed by any of the nonimmunodeficient controls. DNA sequence rearrangements in the viral regulatory region did not appear to be required for shedding of virus, although they were present in ∼20{\%} of samples.",
author = "Rhea-Beth Markowitz and Thompson, {Harry C.} and Mueller, {Jane F.} and Cohen, {Jeffrey A.} and Dynan, {William S.}",
year = "1993",
month = "1",
day = "1",
doi = "10.1093/infdis/167.1.13",
language = "English (US)",
volume = "167",
pages = "13--20",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Incidence of BK Virus and JC virus viruria in human immunodeficiency virus-infected and -uninfected subjects

AU - Markowitz, Rhea-Beth

AU - Thompson, Harry C.

AU - Mueller, Jane F.

AU - Cohen, Jeffrey A.

AU - Dynan, William S.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - BK virus (BKV) and JC virus (JCV) are present within the renal system of most adults. Reactivation may be linked to immunodeficiency, since many of the extant virus strains have been isolated from urine or kidney tissue of patients who were receiving immunosuppressive therapy or who had disorders of the immune system. To more critically evaluate the relationship between immunodeficiency and viruria, urine samples from individuals infected with human immunodeficiency virus (HIV) with various degrees of immunodeficiency were screened for the presence of viral DNA. JCV viruria occurred in 24%–27% of immunocompetent control subjects and was not increased with immunodeficiency. By contrast, there were both qualitative and quantitative changes in BKV viruria in immunodeficient subjects. The incidence of BKV viruria was increased, and some immunodeficient subjects shed BKV at levels up to 3000 times greater than levels shed by any of the nonimmunodeficient controls. DNA sequence rearrangements in the viral regulatory region did not appear to be required for shedding of virus, although they were present in ∼20% of samples.

AB - BK virus (BKV) and JC virus (JCV) are present within the renal system of most adults. Reactivation may be linked to immunodeficiency, since many of the extant virus strains have been isolated from urine or kidney tissue of patients who were receiving immunosuppressive therapy or who had disorders of the immune system. To more critically evaluate the relationship between immunodeficiency and viruria, urine samples from individuals infected with human immunodeficiency virus (HIV) with various degrees of immunodeficiency were screened for the presence of viral DNA. JCV viruria occurred in 24%–27% of immunocompetent control subjects and was not increased with immunodeficiency. By contrast, there were both qualitative and quantitative changes in BKV viruria in immunodeficient subjects. The incidence of BKV viruria was increased, and some immunodeficient subjects shed BKV at levels up to 3000 times greater than levels shed by any of the nonimmunodeficient controls. DNA sequence rearrangements in the viral regulatory region did not appear to be required for shedding of virus, although they were present in ∼20% of samples.

UR - http://www.scopus.com/inward/record.url?scp=0027396830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027396830&partnerID=8YFLogxK

U2 - 10.1093/infdis/167.1.13

DO - 10.1093/infdis/167.1.13

M3 - Article

VL - 167

SP - 13

EP - 20

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -