Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

T. Walter; L. Collenburg; L. Japtok; B. Kleuser; S. Schneider-Schaulies; N. Müller; J. Becam; A. Schubert-Unkmeir; J. N. Kong; E. Bieberich; J. Seibel

doi:10.1039/c6cc02879a

Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

T. Walter, L. Collenburg, L. Japtok, B. Kleuser, S. Schneider-Schaulies, N. Müller, J. Becam, A. Schubert-Unkmeir, J. N. Kong, E. Bieberich, J. Seibel

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

Original language	English (US)
Pages (from-to)	8612-8614
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	55
DOIs	https://doi.org/10.1039/c6cc02879a
State	Published - 2016

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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Walter, T., Collenburg, L., Japtok, L., Kleuser, B., Schneider-Schaulies, S., Müller, N., Becam, J., Schubert-Unkmeir, A., Kong, J. N., Bieberich, E., & Seibel, J. (2016). Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells. Chemical Communications, 52(55), 8612-8614. https://doi.org/10.1039/c6cc02879a

Walter, T, Collenburg, L, Japtok, L, Kleuser, B, Schneider-Schaulies, S, Müller, N, Becam, J, Schubert-Unkmeir, A, Kong, JN, Bieberich, E & Seibel, J 2016, 'Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells', Chemical Communications, vol. 52, no. 55, pp. 8612-8614. https://doi.org/10.1039/c6cc02879a

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title = "Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells",

abstract = "The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.",

author = "T. Walter and L. Collenburg and L. Japtok and B. Kleuser and S. Schneider-Schaulies and N. M{\"u}ller and J. Becam and A. Schubert-Unkmeir and Kong, {J. N.} and E. Bieberich and J. Seibel",

note = "Funding Information: This study was funded through the Deutsche Forschungsgemeinschaft (RU2123) and NIH grants R01 R01AG034389 and R56NS095215 (to E. B.) Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6cc02879a",

language = "English (US)",

volume = "52",

pages = "8612--8614",

journal = "Chemical Communications",

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T2 - N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

AU - Walter, T.

AU - Collenburg, L.

AU - Japtok, L.

AU - Kleuser, B.

AU - Schneider-Schaulies, S.

AU - Müller, N.

AU - Becam, J.

AU - Schubert-Unkmeir, A.

AU - Kong, J. N.

AU - Bieberich, E.

AU - Seibel, J.

N1 - Funding Information: This study was funded through the Deutsche Forschungsgemeinschaft (RU2123) and NIH grants R01 R01AG034389 and R56NS095215 (to E. B.) Publisher Copyright: © 2016 The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

AB - The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

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Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

Abstract

ASJC Scopus subject areas

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