Incorporation of 35 novel gene transcripts into the physical and genetic map of human chromosome 13

Ivan H. Still, Terry Roberts, Britta Bia, Lesleyann Hawthorn, Charles Auffray, John Kenneth Cowell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A panel of somatic cell hybrids carrying a defined set of rearrangements involving chromosome 13 has been used to assign 35 novel gene transcripts regionally. The positions of the chromosome 13 breakpoints in each somatic cell hybrid have previously been defined relative to the Genethon genetic linkage map. As a result, the position of each gene transcript has been determined relative to both the physical and the genetic linkage maps. Analysis of the distribution of these gene transcripts indicates a slight overrepresentation toward locations on the distal long arm of chromosome 13, with no localizations noted in the 13q22-q31 region. Seven of these novel gene transcripts and the gene encoding small ribonucleoprotein U6 have been mapped to YACs known to contain Genethon microsatellite markers, thereby providing further sublocalization relative to the genetic map. The positioning of these gene transcripts within the genetic and physical maps provides candidate genes for disease loci that are being mapped to the same intervals on the chromosome.

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalGenomics
Volume33
Issue number2
DOIs
StatePublished - Apr 15 1996
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 13
Human Chromosomes
Genes
Genetic Linkage
Hybrid Cells
Chromosome Breakpoints
Ribonucleoproteins
Gene Order
Microsatellite Repeats
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Incorporation of 35 novel gene transcripts into the physical and genetic map of human chromosome 13. / Still, Ivan H.; Roberts, Terry; Bia, Britta; Hawthorn, Lesleyann; Auffray, Charles; Cowell, John Kenneth.

In: Genomics, Vol. 33, No. 2, 15.04.1996, p. 159-166.

Research output: Contribution to journalArticle

Still, Ivan H. ; Roberts, Terry ; Bia, Britta ; Hawthorn, Lesleyann ; Auffray, Charles ; Cowell, John Kenneth. / Incorporation of 35 novel gene transcripts into the physical and genetic map of human chromosome 13. In: Genomics. 1996 ; Vol. 33, No. 2. pp. 159-166.
@article{8403f0d54a814ecea970eba36319ceb5,
title = "Incorporation of 35 novel gene transcripts into the physical and genetic map of human chromosome 13",
abstract = "A panel of somatic cell hybrids carrying a defined set of rearrangements involving chromosome 13 has been used to assign 35 novel gene transcripts regionally. The positions of the chromosome 13 breakpoints in each somatic cell hybrid have previously been defined relative to the Genethon genetic linkage map. As a result, the position of each gene transcript has been determined relative to both the physical and the genetic linkage maps. Analysis of the distribution of these gene transcripts indicates a slight overrepresentation toward locations on the distal long arm of chromosome 13, with no localizations noted in the 13q22-q31 region. Seven of these novel gene transcripts and the gene encoding small ribonucleoprotein U6 have been mapped to YACs known to contain Genethon microsatellite markers, thereby providing further sublocalization relative to the genetic map. The positioning of these gene transcripts within the genetic and physical maps provides candidate genes for disease loci that are being mapped to the same intervals on the chromosome.",
author = "Still, {Ivan H.} and Terry Roberts and Britta Bia and Lesleyann Hawthorn and Charles Auffray and Cowell, {John Kenneth}",
year = "1996",
month = "4",
day = "15",
doi = "10.1006/geno.1996.0179",
language = "English (US)",
volume = "33",
pages = "159--166",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Incorporation of 35 novel gene transcripts into the physical and genetic map of human chromosome 13

AU - Still, Ivan H.

AU - Roberts, Terry

AU - Bia, Britta

AU - Hawthorn, Lesleyann

AU - Auffray, Charles

AU - Cowell, John Kenneth

PY - 1996/4/15

Y1 - 1996/4/15

N2 - A panel of somatic cell hybrids carrying a defined set of rearrangements involving chromosome 13 has been used to assign 35 novel gene transcripts regionally. The positions of the chromosome 13 breakpoints in each somatic cell hybrid have previously been defined relative to the Genethon genetic linkage map. As a result, the position of each gene transcript has been determined relative to both the physical and the genetic linkage maps. Analysis of the distribution of these gene transcripts indicates a slight overrepresentation toward locations on the distal long arm of chromosome 13, with no localizations noted in the 13q22-q31 region. Seven of these novel gene transcripts and the gene encoding small ribonucleoprotein U6 have been mapped to YACs known to contain Genethon microsatellite markers, thereby providing further sublocalization relative to the genetic map. The positioning of these gene transcripts within the genetic and physical maps provides candidate genes for disease loci that are being mapped to the same intervals on the chromosome.

AB - A panel of somatic cell hybrids carrying a defined set of rearrangements involving chromosome 13 has been used to assign 35 novel gene transcripts regionally. The positions of the chromosome 13 breakpoints in each somatic cell hybrid have previously been defined relative to the Genethon genetic linkage map. As a result, the position of each gene transcript has been determined relative to both the physical and the genetic linkage maps. Analysis of the distribution of these gene transcripts indicates a slight overrepresentation toward locations on the distal long arm of chromosome 13, with no localizations noted in the 13q22-q31 region. Seven of these novel gene transcripts and the gene encoding small ribonucleoprotein U6 have been mapped to YACs known to contain Genethon microsatellite markers, thereby providing further sublocalization relative to the genetic map. The positioning of these gene transcripts within the genetic and physical maps provides candidate genes for disease loci that are being mapped to the same intervals on the chromosome.

UR - http://www.scopus.com/inward/record.url?scp=0029876552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029876552&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.0179

DO - 10.1006/geno.1996.0179

M3 - Article

VL - 33

SP - 159

EP - 166

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -