Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome

Hesham M. Amin, Iman Jilani, Elihu H. Estey, Michael J. Keating, Amanda L. Dey, Taghi Manshouri, Hagop M. Kantarjian, Zeev Estrov, Jorge E. Cortes, Deborah A. Thomas, Francis J. Giles, Maher Albitar

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The hallmark of myelodysplastic syndrome (MDS) is enhanced apoptosis in myeloid, erythroid, and megakaryocytic cells in the bone marrow leading to ineffective hematopoiesis. Recent studies suggested that immunological and microenvironmental factors play a role in the pathophysiology of this disease. We report a significant increase in apoptosis in bone marrow B lymphocytes in MDS as compared to that found in acute myeloid leukemia and healthy controls. Furthermore, we demonstrate that patients with refractory anemia with excess blasts in transformation (RAEB-T) had apoptosis levels in lymphocytes similar to those seen in other subtypes of MDS. Our findings suggest that the alterations in B lymphocytes in the form of increased apoptosis can be seen in MDS and support the concept that immune modulation plays a role in the pathophysiology of MDS.

Original languageEnglish (US)
Pages (from-to)1866-1868
Number of pages3
JournalBlood
Volume102
Issue number5
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Amin, H. M., Jilani, I., Estey, E. H., Keating, M. J., Dey, A. L., Manshouri, T., Kantarjian, H. M., Estrov, Z., Cortes, J. E., Thomas, D. A., Giles, F. J., & Albitar, M. (2003). Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome. Blood, 102(5), 1866-1868. https://doi.org/10.1182/blood-2003-01-0221