Increased insulin secretion in puberty

A compensatory response to reductions in insulin sensitivity

Sonia Caprio, Gerd Plewe, Michael Peter Diamond, Donald C. Simonson, Susan D. Boulware, Robert S. Sherwin, William V. Tamborlane

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

Recent studies have suggested that insulin action is reduced during puberty in normal children. To determine whether such resistance leads to excessive insulin secretion, we used the hyperglycemic clamp technique to produce a standard hyperglycemic stimulus (125 mg/dl above fasting levels for 120 minutes) in 9 preadolescent and 14 adolescent healthy children and in 14 normal adults. Fasting plasma insulin and C-peptide concentrations were higher in adolescents than in preadolescents and adults (p≤0.02). Despite identical glucose increments during the glucose clamp procedure, both first- and second-phase plasma insulin and C-peptide responses were also markedly greater in adolescents than in preadolescents or adults (p<0.01 vs. other groups). Despite sharply increased insulin responses in adolescents, the amount of exogenous glucose required to maintain hyperglycemia was similar in all three groups. Insulin responses in the children were directly correlated with fasting plasma levels of insulin-like growth factor I (r=0.60 to 0.70, p<0.01). We conclude that glucose-stimulated insulin secretion is normally increased during puberty, a response that may compensate for puberty-induced defects in insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)963-967
Number of pages5
JournalThe Journal of Pediatrics
Volume114
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Puberty
Insulin Resistance
Insulin
Fasting
C-Peptide
Glucose
Glucose Clamp Technique
Insulin-Like Growth Factor I
Hyperglycemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Increased insulin secretion in puberty : A compensatory response to reductions in insulin sensitivity. / Caprio, Sonia; Plewe, Gerd; Diamond, Michael Peter; Simonson, Donald C.; Boulware, Susan D.; Sherwin, Robert S.; Tamborlane, William V.

In: The Journal of Pediatrics, Vol. 114, No. 6, 01.01.1989, p. 963-967.

Research output: Contribution to journalArticle

Caprio, Sonia ; Plewe, Gerd ; Diamond, Michael Peter ; Simonson, Donald C. ; Boulware, Susan D. ; Sherwin, Robert S. ; Tamborlane, William V. / Increased insulin secretion in puberty : A compensatory response to reductions in insulin sensitivity. In: The Journal of Pediatrics. 1989 ; Vol. 114, No. 6. pp. 963-967.
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