Abstract
Recent studies have suggested that insulin action is reduced during puberty in normal children. To determine whether such resistance leads to excessive insulin secretion, we used the hyperglycemic clamp technique to produce a standard hyperglycemic stimulus (125 mg/dl above fasting levels for 120 minutes) in 9 preadolescent and 14 adolescent healthy children and in 14 normal adults. Fasting plasma insulin and C-peptide concentrations were higher in adolescents than in preadolescents and adults (p≤0.02). Despite identical glucose increments during the glucose clamp procedure, both first- and second-phase plasma insulin and C-peptide responses were also markedly greater in adolescents than in preadolescents or adults (p<0.01 vs. other groups). Despite sharply increased insulin responses in adolescents, the amount of exogenous glucose required to maintain hyperglycemia was similar in all three groups. Insulin responses in the children were directly correlated with fasting plasma levels of insulin-like growth factor I (r=0.60 to 0.70, p<0.01). We conclude that glucose-stimulated insulin secretion is normally increased during puberty, a response that may compensate for puberty-induced defects in insulin sensitivity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 963-967 |
| Number of pages | 5 |
| Journal | The Journal of Pediatrics |
| Volume | 114 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Increased insulin secretion in puberty : A compensatory response to reductions in insulin sensitivity. / Caprio, Sonia; Plewe, Gerd; Diamond, Michael Peter; Simonson, Donald C.; Boulware, Susan D.; Sherwin, Robert S.; Tamborlane, William V.
In: The Journal of Pediatrics, Vol. 114, No. 6, 01.01.1989, p. 963-967.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased insulin secretion in puberty
T2 - A compensatory response to reductions in insulin sensitivity
AU - Caprio, Sonia
AU - Plewe, Gerd
AU - Diamond, Michael Peter
AU - Simonson, Donald C.
AU - Boulware, Susan D.
AU - Sherwin, Robert S.
AU - Tamborlane, William V.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Recent studies have suggested that insulin action is reduced during puberty in normal children. To determine whether such resistance leads to excessive insulin secretion, we used the hyperglycemic clamp technique to produce a standard hyperglycemic stimulus (125 mg/dl above fasting levels for 120 minutes) in 9 preadolescent and 14 adolescent healthy children and in 14 normal adults. Fasting plasma insulin and C-peptide concentrations were higher in adolescents than in preadolescents and adults (p≤0.02). Despite identical glucose increments during the glucose clamp procedure, both first- and second-phase plasma insulin and C-peptide responses were also markedly greater in adolescents than in preadolescents or adults (p<0.01 vs. other groups). Despite sharply increased insulin responses in adolescents, the amount of exogenous glucose required to maintain hyperglycemia was similar in all three groups. Insulin responses in the children were directly correlated with fasting plasma levels of insulin-like growth factor I (r=0.60 to 0.70, p<0.01). We conclude that glucose-stimulated insulin secretion is normally increased during puberty, a response that may compensate for puberty-induced defects in insulin sensitivity.
AB - Recent studies have suggested that insulin action is reduced during puberty in normal children. To determine whether such resistance leads to excessive insulin secretion, we used the hyperglycemic clamp technique to produce a standard hyperglycemic stimulus (125 mg/dl above fasting levels for 120 minutes) in 9 preadolescent and 14 adolescent healthy children and in 14 normal adults. Fasting plasma insulin and C-peptide concentrations were higher in adolescents than in preadolescents and adults (p≤0.02). Despite identical glucose increments during the glucose clamp procedure, both first- and second-phase plasma insulin and C-peptide responses were also markedly greater in adolescents than in preadolescents or adults (p<0.01 vs. other groups). Despite sharply increased insulin responses in adolescents, the amount of exogenous glucose required to maintain hyperglycemia was similar in all three groups. Insulin responses in the children were directly correlated with fasting plasma levels of insulin-like growth factor I (r=0.60 to 0.70, p<0.01). We conclude that glucose-stimulated insulin secretion is normally increased during puberty, a response that may compensate for puberty-induced defects in insulin sensitivity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024364978&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(89)80438-X
DO - 10.1016/S0022-3476(89)80438-X
M3 - Article
VL - 114
SP - 963
EP - 967
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -