Increased interleukin 1β in human skeletal muscle after exercise

J. G. Cannon, R. A. Fielding, M. A. Fiatarone, S. F. Orencole, C. A. Dinarello, W. J. Evans

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Interleukin 1β (IL-1β) is a protein released from blood monocytes and related cells in response to infectious or inflammatory stimuli. Although IL-1β is elevated in the circulation for only a few hours after an acute inflammatory challenge or exercise, it has been proposed to mediate anabolic and catabolic processes that can last for several days. In this report, eccentric exercise was used as a noninfectious inflammatory stimulus. IL-1β was found in muscle tissue up to 5 days after exercise using specific immunohistochemical tissue staining. Increased IL-1β immunoreactivity was observed in muscle tissue from four human subjects who performed the exercise, but not in tissue obtained at the same time intervals from two subjects who did not exercise. Little immunohistochemical evidence of interleukin-1α or tumor necrosis factor α was observed before or after exercise. These results implicate IL-1β in the metabolic adaptations of muscle tissue, which occur in response to noninfectious stresses.

Original languageEnglish (US)
Pages (from-to)26/2
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume257
Issue number2
StatePublished - Jan 1 1989

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Interleukin-1
Skeletal Muscle
Muscles
Blood Proteins
Monocytes
Tumor Necrosis Factor-alpha
Staining and Labeling

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Cannon, J. G., Fielding, R. A., Fiatarone, M. A., Orencole, S. F., Dinarello, C. A., & Evans, W. J. (1989). Increased interleukin 1β in human skeletal muscle after exercise. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 257(2), 26/2.

Increased interleukin 1β in human skeletal muscle after exercise. / Cannon, J. G.; Fielding, R. A.; Fiatarone, M. A.; Orencole, S. F.; Dinarello, C. A.; Evans, W. J.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 257, No. 2, 01.01.1989, p. 26/2.

Research output: Contribution to journalArticle

Cannon, JG, Fielding, RA, Fiatarone, MA, Orencole, SF, Dinarello, CA & Evans, WJ 1989, 'Increased interleukin 1β in human skeletal muscle after exercise', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 257, no. 2, pp. 26/2.
Cannon JG, Fielding RA, Fiatarone MA, Orencole SF, Dinarello CA, Evans WJ. Increased interleukin 1β in human skeletal muscle after exercise. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1989 Jan 1;257(2):26/2.
Cannon, J. G. ; Fielding, R. A. ; Fiatarone, M. A. ; Orencole, S. F. ; Dinarello, C. A. ; Evans, W. J. / Increased interleukin 1β in human skeletal muscle after exercise. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1989 ; Vol. 257, No. 2. pp. 26/2.
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