Increased likelihood of post-polycythemia vera myelofibrosis in Ph-negative MPN patients with chromosome 12 abnormalities

Christopher B. Benton, Maria Tanaka, Catherine Wilson, Sherry Pierce, Lingsha Zhou, Jorge Cortes, Hagop Kantarjian, Srdan Verstovsek

Research output: Contribution to journalArticle

Abstract

Chromosome 12 (Chr12) abnormalities have been described for individual patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-neg MPN), however the frequency, characteristics, and outcomes of such patients as a whole have not been investigated. We reviewed a database of 1787 consecutive Ph-neg MPN patients seen at our institution and determined that 2% of Ph-neg MPN patients harbored an alteration involving Chr12 by cytogenetic evaluation. Retrospective chart review revealed that patients with Chr12 abnormalities had a higher likelihood of having myelofibrosis (MF) compared to patients without a Chr12 abnormality, and were more likely to have post-polycythemia vera MF. The most common alterations in Chr12 in MF patients involved 12q13, 12q15, 12q24, and trisomy 12, and >40% of Chr12 Ph-neg MPN patients had cytogenetic evolution. Chr12 abnormalities did not significantly correlate with JAK2 status, progression to acute myeloid leukemia, or survival, however patients with 12q24 abnormalities trended toward poorer outcomes.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalLeukemia Research
Volume39
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 12
Polycythemia Vera
Primary Myelofibrosis
Chromosome Aberrations
Philadelphia Chromosome
Cytogenetics
Neoplasms
Trisomy
Acute Myeloid Leukemia
Databases
Survival

Keywords

  • Chromosome aberrations
  • Myelofibrosis
  • Myeloproliferative neoplasms
  • Polycythemia vera

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Increased likelihood of post-polycythemia vera myelofibrosis in Ph-negative MPN patients with chromosome 12 abnormalities. / Benton, Christopher B.; Tanaka, Maria; Wilson, Catherine; Pierce, Sherry; Zhou, Lingsha; Cortes, Jorge; Kantarjian, Hagop; Verstovsek, Srdan.

In: Leukemia Research, Vol. 39, No. 4, 01.04.2015, p. 419-423.

Research output: Contribution to journalArticle

Benton, Christopher B. ; Tanaka, Maria ; Wilson, Catherine ; Pierce, Sherry ; Zhou, Lingsha ; Cortes, Jorge ; Kantarjian, Hagop ; Verstovsek, Srdan. / Increased likelihood of post-polycythemia vera myelofibrosis in Ph-negative MPN patients with chromosome 12 abnormalities. In: Leukemia Research. 2015 ; Vol. 39, No. 4. pp. 419-423.
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