Increased plasma interleukin-1 activity in women after ovulation

Joseph Gerard Cannon, Charles A. Dinarello

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

The polypeptide interleukin-1 mediates many host responses to infection and inflammation. A method was developed for studying interleukin-1 levels in human plasma from febrile patients. Interleukin-1 activity was also consistently found in plasma samples from women in the luteal phase of their menstrual cycle. This activity was neutralized by a specific antiserum to human interleukin-1 and was low in plasma from healthy men and preovulatory women. Thus interleukin-1 appears to have a role in normal physiological conditions as well as in disease states.

Original languageEnglish (US)
Pages (from-to)1247-1249
Number of pages3
JournalScience
Volume227
Issue number4691
DOIs
StatePublished - Jan 1 1985

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Ovulation
Interleukin-1
Luteal Phase
Immune Sera
Fever
Inflammation
Peptides
Infection

ASJC Scopus subject areas

  • General

Cite this

Increased plasma interleukin-1 activity in women after ovulation. / Cannon, Joseph Gerard; Dinarello, Charles A.

In: Science, Vol. 227, No. 4691, 01.01.1985, p. 1247-1249.

Research output: Contribution to journalArticle

Cannon, JG & Dinarello, CA 1985, 'Increased plasma interleukin-1 activity in women after ovulation', Science, vol. 227, no. 4691, pp. 1247-1249. https://doi.org/10.1126/science.3871966
Cannon, Joseph Gerard ; Dinarello, Charles A. / Increased plasma interleukin-1 activity in women after ovulation. In: Science. 1985 ; Vol. 227, No. 4691. pp. 1247-1249.
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