Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice

Gladis Fragoso, Edmundo Lamoyi, Andrew Mellor, Ciro Lomeli, Marisela Hernández, Edda Sciutto

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant. In this study, we investigated the role of Qa- 2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F1 and BALB/cAnN x (BALB/cJ x BALB/cAnN)F1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites were recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

Original languageEnglish (US)
Pages (from-to)760-764
Number of pages5
JournalInfection and Immunity
Volume66
Issue number2
StatePublished - Feb 25 1998

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Fragoso, G., Lamoyi, E., Mellor, A., Lomeli, C., Hernández, M., & Sciutto, E. (1998). Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice. Infection and Immunity, 66(2), 760-764.