Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice

Gladis Fragoso, Edmundo Lamoyi, Andrew Mellor, Ciro Lomeli, Marisela Hernández, Edda Sciutto

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Abstract

We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant. In this study, we investigated the role of Qa- 2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F1 and BALB/cAnN x (BALB/cJ x BALB/cAnN)F1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites were recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

Original languageEnglish (US)
Pages (from-to)760-764
Number of pages5
JournalInfection and Immunity
Volume66
Issue number2
StatePublished - Feb 25 1998

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Taenia
Cysticercosis
Transgenic Mice
Major Histocompatibility Complex
Histocompatibility Antigens
Parasites
Infection
Q surface antigens

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Fragoso, G., Lamoyi, E., Mellor, A., Lomeli, C., Hernández, M., & Sciutto, E. (1998). Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice. Infection and Immunity, 66(2), 760-764.

Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice. / Fragoso, Gladis; Lamoyi, Edmundo; Mellor, Andrew; Lomeli, Ciro; Hernández, Marisela; Sciutto, Edda.

In: Infection and Immunity, Vol. 66, No. 2, 25.02.1998, p. 760-764.

Research output: Contribution to journalArticle

Fragoso, G, Lamoyi, E, Mellor, A, Lomeli, C, Hernández, M & Sciutto, E 1998, 'Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice', Infection and Immunity, vol. 66, no. 2, pp. 760-764.
Fragoso G, Lamoyi E, Mellor A, Lomeli C, Hernández M, Sciutto E. Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice. Infection and Immunity. 1998 Feb 25;66(2):760-764.
Fragoso, Gladis ; Lamoyi, Edmundo ; Mellor, Andrew ; Lomeli, Ciro ; Hernández, Marisela ; Sciutto, Edda. / Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice. In: Infection and Immunity. 1998 ; Vol. 66, No. 2. pp. 760-764.
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