Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis

William H. Hoffman, Gregory G Passmore, David W. Hannon, Monica V. Talor, Pam Fox, Catherine Brailer, Dynita Haislip, Cynthia Keel, Glenn Harris, Noel R. Rose, Irma Fiordalisi, Daniela Čiháková

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Abstract

Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabetic ketoacidosis (DKA). Twenty seven of the 39 measured cytokines/chemokines were elevated at 6-12 hours into treatment of DKA compared to values after DKA resolution. Eight patients displayed at least one parameter of diastolic abnormality (DA) during acute DKA. Significant associations were present between nine of the cytokine/chemokine levels and the DA over time. Interestingly, four of these nine interactive cytokines (GM-CSF, G-CSF, IL-12p40, IL-17) are associated with a Th17 mediated cell response. Both the DA and CCL7 and IL-12p40, had independent associations with African American patients. Thus, we report occurrence of a systemic inflammatory response and the presence of cardiac diastolic dysfunction in a subset of young T1DM patients during acute DKA.

Original languageEnglish (US)
Article numbere71905
JournalPloS one
Volume8
Issue number8
DOIs
StatePublished - Aug 27 2013

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Diabetic Ketoacidosis
ketosis
cytokines
Chemokines
Interleukin-12 Subunit p40
Cytokines
chemokines
Interleukin-17
Diabetic Cardiomyopathies
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Th17 Cells
cardiomyopathy
African Americans
cardiac output
pathogenesis
inflammation
cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis. / Hoffman, William H.; Passmore, Gregory G; Hannon, David W.; Talor, Monica V.; Fox, Pam; Brailer, Catherine; Haislip, Dynita; Keel, Cynthia; Harris, Glenn; Rose, Noel R.; Fiordalisi, Irma; Čiháková, Daniela.

In: PloS one, Vol. 8, No. 8, e71905, 27.08.2013.

Research output: Contribution to journalArticle

Hoffman, WH, Passmore, GG, Hannon, DW, Talor, MV, Fox, P, Brailer, C, Haislip, D, Keel, C, Harris, G, Rose, NR, Fiordalisi, I & Čiháková, D 2013, 'Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis', PloS one, vol. 8, no. 8, e71905. https://doi.org/10.1371/journal.pone.0071905
Hoffman, William H. ; Passmore, Gregory G ; Hannon, David W. ; Talor, Monica V. ; Fox, Pam ; Brailer, Catherine ; Haislip, Dynita ; Keel, Cynthia ; Harris, Glenn ; Rose, Noel R. ; Fiordalisi, Irma ; Čiháková, Daniela. / Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis. In: PloS one. 2013 ; Vol. 8, No. 8.
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