Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment

Aicha Jrad-Lamine, Joelle Henry-Berger, Christelle Damon-Soubeyrand, Fabrice Saez, Ayhan Kocer, Laurent Janny, Hanae Pons-Rejraji, David H. Munn, Andrew L. Mellor, Najoua Gharbi, Rémi Cadet, Rachel Guiton, Robert J. Aitken, Joël R. Drevet

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Abstract

The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1-/- model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1-/- animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.

Original languageEnglish (US)
Article numbere66494
JournalPloS one
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 20 2013

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Jrad-Lamine, A., Henry-Berger, J., Damon-Soubeyrand, C., Saez, F., Kocer, A., Janny, L., ... Drevet, J. R. (2013). Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment. PloS one, 8(6), [e66494]. https://doi.org/10.1371/journal.pone.0066494