Abstract
The priming of an appropriate anti-tumor T cell response rarely results in the rejection of established tumors. The characteristics of tumors that allow them to evade a T cell-mediated rejection are unknown for many tumors. We report on evidence that the expression of the immunosuppressive enzyme, indoleamine 2,3-dioxygenase (IDO) by mononuclear cells that invade tumors and tumor-draining lymph nodes, is I mechanism that may account for this observation. Lewis lung carcinoma (LLC) cells stimulated a more robust allogeneic T cell response in vitro in the presence of a competitive inhibitor of IDO, I-methyl tryptophan. When administered in vivo this inhibitor also resulted in delayed LLC tumor growth in syngeneic mice. Our study provides evidence for a novel mechanism whereby tumors evade rejection by the immune system, and suggests the possibility that inhibiting IDO may be developed as an anti-cancer immunotherapeutic strategy.
Original language | English (US) |
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Pages (from-to) | 151-155 |
Number of pages | 5 |
Journal | International Journal of Cancer |
Volume | 101 |
Issue number | 2 |
DOIs | |
State | Published - Sep 10 2002 |
Keywords
- Indoleamine 2,3-dioxygenase
- T cell
- Tumor
ASJC Scopus subject areas
- Oncology
- Cancer Research