Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy

Andrew L. Mellor, Phillip Chandler, Geon Kook Lee, Theodore Johnson, Derin B. Keskin, Jeffrey Lee, David H. Munn

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalJournal of Reproductive Immunology
Volume57
Issue number1-2
DOIs
StatePublished - Oct 31 2002

Keywords

  • Immunosuppression
  • Indoleamine 2,3-dioxygenase
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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