Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy

Andrew L. Mellor; Phillip Chandler; Geon Kook Lee; Theodore Johnson; Derin B. Keskin; Jeffrey Lee; David H. Munn

doi:10.1016/S0165-0378(02)00040-2

Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy

Andrew L. Mellor, Phillip Chandler, Geon Kook Lee, Theodore Johnson, Derin B. Keskin, Jeffrey Lee, David H. Munn

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.

Original language	English (US)
Pages (from-to)	143-150
Number of pages	8
Journal	Journal of Reproductive Immunology
Volume	57
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-0378(02)00040-2
State	Published - Oct 31 2002

Keywords

Immunosuppression
Indoleamine 2,3-dioxygenase
Pregnancy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1016/S0165-0378(02)00040-2

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abstract = "Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.",

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AU - Keskin, Derin B.

AU - Lee, Jeffrey

AU - Munn, David H.

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AB - Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.

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Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy

Abstract

Keywords

ASJC Scopus subject areas

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