Induction of demyelination by intraneural injection of antibodies against sulfoglucuronyl paragloboside

Yasuhiro Maeda, John W. Bigbee, Reiko Maeda, Nobuyuki Miyatani, Robert G. Kalb, Robert K. Yu

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Sulfoglucuronyl glycolipids (SGGLs) carry the glucuronyl 3-sulfate (HNK-1) epitope which is recognized by monoclonal IgM paraproteins from patients with demyelinating polyneuropathy. We report that intraneural injections of rat anti-SGGL antibodies induce demyelination in rat sciatic nerve, along with mild to moderate clinical symptoms. Morphologically, vesiculation and loosening of the myelin sheath were observed 3 h postinjection, followed by extensive demyelination and macrophage infiltration after 4 days. Since the antiSGGL antibodies showed no cross-reactivity with other components in rat sciatic nerve, these results indicate that SGGLs alone can serve as the target antigens in demyelinating neuropathy.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalExperimental Neurology
Volume113
Issue number2
DOIs
StatePublished - Aug 1991
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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