Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Meghan Elizabeth McGee Lawrence; David F. Razidlo

doi:10.1007/978-1-4939-1619-1_14

Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Meghan Elizabeth McGee Lawrence, David F. Razidlo

Research output: Contribution to journal › Article › peer-review

Abstract

Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

Original language	English (US)
Pages (from-to)	183-192
Number of pages	10
Journal	Methods in Molecular Biology
Volume	1226
DOIs	https://doi.org/10.1007/978-1-4939-1619-1_14
State	Published - Jan 1 2015
Externally published	Yes

Keywords

Fracture healing
Intramembranous bone formation
Mouse model
Stabilized defect repair

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/978-1-4939-1619-1_14

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title = "Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration",

abstract = "Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.",

keywords = "Fracture healing, Intramembranous bone formation, Mouse model, Stabilized defect repair",

author = "{McGee Lawrence}, {Meghan Elizabeth} and Razidlo, {David F.}",

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AU - Razidlo, David F.

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N2 - Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

AB - Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

KW - Fracture healing

KW - Intramembranous bone formation

KW - Mouse model

KW - Stabilized defect repair

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Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Abstract

Keywords

ASJC Scopus subject areas

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