Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Research output: Contribution to journalArticlepeer-review

Abstract

Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalMethods in Molecular Biology
Volume1226
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Fracture healing
  • Intramembranous bone formation
  • Mouse model
  • Stabilized defect repair

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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