Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Bone is a regenerative tissue with an innate ability to self-remodel in response to environmental stimuli and the need to repair damage. Rodent models of fracture healing, and in particular genetic mouse models, can be used to study the contributions of specific molecular switches to skeletal repair, as well as to recreate and exacerbate biological development and repair mechanisms in postnatal skeletons. Here, we describe methodology for producing fully stabilized, single-cortex defects in mouse femurs to study mechanisms of intramembranous bone regeneration.

Original languageEnglish (US)
Title of host publicationOsteoporosis and Osteoarthritis
PublisherSpringer New York
Number of pages10
ISBN (Electronic)9781493916191
ISBN (Print)9781493916184
StatePublished - Oct 20 2014



  • Fracture healing
  • Intramembranous bone formation
  • Mouse model
  • Stabilized defect repair

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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