Inflammatory cytokines as predictive markers for early detection and progression of diabetic nephropathy

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22 Citations (Scopus)

Abstract

Diabetic nephropathy is a major complication of diabetes mellitus and the leading cause of end-stage renal disease. Both hyperglycemia and hypertension (systemic and/or intraglomerular) are established causal factors for diabetic nephropathy. Nonetheless, there is growing evidence that activated innate immunity and inflammation are also contributing factors to the pathogenesis of diabetic nephropathy. This notion is based on increasing evidence indicating that both cytokines-chemokines and pro-fibrotic growth factors are important players in the progression of diabetic nephropathy, effectively accelerating and exacerbating inflammatory and fibrotic processes leading to endstage renal disease. In this review, we focus on several predominant cytokines-chemokines as potential predictive markers for diabetic nephropathy. These cytokineschemokines may also be helpful as biomarkers to monitor the progression of the disease and the impact of interventional modalities aimed at halting eventual manifestation of end-stage renal disease in diabetic patients.

Original languageEnglish (US)
Pages (from-to)117-129
Number of pages13
JournalEPMA Journal
Volume1
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Diabetic Nephropathies
Cytokines
Chemokines
Chronic Kidney Failure
Biomarkers
Medical problems
Diabetes Complications
Intercellular Signaling Peptides and Proteins
Innate Immunity
Hyperglycemia
Disease Progression
Hypertension
Inflammation
Kidney

Keywords

  • Advanced predictive diagnostics
  • Cytokines/chemokines
  • Disease monitoring
  • Major complication of diabetes
  • Personalized patient treatment
  • Renal disease

ASJC Scopus subject areas

  • Health Policy
  • Biochemistry, medical
  • Drug Discovery

Cite this

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abstract = "Diabetic nephropathy is a major complication of diabetes mellitus and the leading cause of end-stage renal disease. Both hyperglycemia and hypertension (systemic and/or intraglomerular) are established causal factors for diabetic nephropathy. Nonetheless, there is growing evidence that activated innate immunity and inflammation are also contributing factors to the pathogenesis of diabetic nephropathy. This notion is based on increasing evidence indicating that both cytokines-chemokines and pro-fibrotic growth factors are important players in the progression of diabetic nephropathy, effectively accelerating and exacerbating inflammatory and fibrotic processes leading to endstage renal disease. In this review, we focus on several predominant cytokines-chemokines as potential predictive markers for diabetic nephropathy. These cytokineschemokines may also be helpful as biomarkers to monitor the progression of the disease and the impact of interventional modalities aimed at halting eventual manifestation of end-stage renal disease in diabetic patients.",
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T1 - Inflammatory cytokines as predictive markers for early detection and progression of diabetic nephropathy

AU - Elmarakby, Ahmed Abdelrazik

AU - Abdelsayed, Rafik A

AU - Liu, Jun Yao

AU - Mozaffari, Mahmood S

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Diabetic nephropathy is a major complication of diabetes mellitus and the leading cause of end-stage renal disease. Both hyperglycemia and hypertension (systemic and/or intraglomerular) are established causal factors for diabetic nephropathy. Nonetheless, there is growing evidence that activated innate immunity and inflammation are also contributing factors to the pathogenesis of diabetic nephropathy. This notion is based on increasing evidence indicating that both cytokines-chemokines and pro-fibrotic growth factors are important players in the progression of diabetic nephropathy, effectively accelerating and exacerbating inflammatory and fibrotic processes leading to endstage renal disease. In this review, we focus on several predominant cytokines-chemokines as potential predictive markers for diabetic nephropathy. These cytokineschemokines may also be helpful as biomarkers to monitor the progression of the disease and the impact of interventional modalities aimed at halting eventual manifestation of end-stage renal disease in diabetic patients.

AB - Diabetic nephropathy is a major complication of diabetes mellitus and the leading cause of end-stage renal disease. Both hyperglycemia and hypertension (systemic and/or intraglomerular) are established causal factors for diabetic nephropathy. Nonetheless, there is growing evidence that activated innate immunity and inflammation are also contributing factors to the pathogenesis of diabetic nephropathy. This notion is based on increasing evidence indicating that both cytokines-chemokines and pro-fibrotic growth factors are important players in the progression of diabetic nephropathy, effectively accelerating and exacerbating inflammatory and fibrotic processes leading to endstage renal disease. In this review, we focus on several predominant cytokines-chemokines as potential predictive markers for diabetic nephropathy. These cytokineschemokines may also be helpful as biomarkers to monitor the progression of the disease and the impact of interventional modalities aimed at halting eventual manifestation of end-stage renal disease in diabetic patients.

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KW - Cytokines/chemokines

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KW - Major complication of diabetes

KW - Personalized patient treatment

KW - Renal disease

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