Inflammatory myopathy, IgA deficiency, and intestinal malabsorption

James Edwin Carroll, Arnold Silverman, Yoshinari Isobe, William R. Brown, K. Alan Kelts, Michael H. Brooke

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Two IgA-deficient children with inflammatory myopathy and intestinal malabsorption were evaluated. The myopathy was characterized by weakness of facial and proximal limb muscles, increased serum concentrations of lactic dehydrogenase and creatine phosphokinase, and histologic evidence of inflammation and degeneration of muscle fibers. Features of the intestinal abnormality were blunted villi, interstitial inflammation, and reduction in IgA-containing plasma cells and IgA content of epithelial cells. The myopathy and malabsorption improved with corticosteroid treatment. Circulating antibodies to striated muscle could not be demonstrated in either patient, but one had antibodies to milk and chicken serum proteins. We speculate that IgA deficiency may predispose to the development of inflammatory myopathy.

Original languageEnglish (US)
Pages (from-to)216-219
Number of pages4
JournalThe Journal of Pediatrics
Volume89
Issue number2
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

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IgA Deficiency
Myositis
Immunoglobulin A
Muscular Diseases
Milk
Inflammation
Muscles
Striated Muscle
Antibodies
Creatine Kinase
Plasma Cells
Blood Proteins
Chickens
Adrenal Cortex Hormones
Oxidoreductases
Extremities
Epithelial Cells
Serum
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Inflammatory myopathy, IgA deficiency, and intestinal malabsorption. / Carroll, James Edwin; Silverman, Arnold; Isobe, Yoshinari; Brown, William R.; Kelts, K. Alan; Brooke, Michael H.

In: The Journal of Pediatrics, Vol. 89, No. 2, 01.01.1976, p. 216-219.

Research output: Contribution to journalArticle

Carroll, JE, Silverman, A, Isobe, Y, Brown, WR, Kelts, KA & Brooke, MH 1976, 'Inflammatory myopathy, IgA deficiency, and intestinal malabsorption', The Journal of Pediatrics, vol. 89, no. 2, pp. 216-219. https://doi.org/10.1016/S0022-3476(76)80451-9
Carroll, James Edwin ; Silverman, Arnold ; Isobe, Yoshinari ; Brown, William R. ; Kelts, K. Alan ; Brooke, Michael H. / Inflammatory myopathy, IgA deficiency, and intestinal malabsorption. In: The Journal of Pediatrics. 1976 ; Vol. 89, No. 2. pp. 216-219.
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