TY - JOUR
T1 - Influence of acute-phase proteins on the activity of natural killer cells
AU - Okumura, Yuzo
AU - Kudo, Jiro
AU - Ikuta, Tohru
AU - Kurokawa, Satoshi
AU - Ishibashi, Hiromi
AU - Okubo, Hideo
PY - 1985/6/1
Y1 - 1985/6/1
N2 - The effects of α1-antitrypsin (α1,-AT), α1,-acid glycoprotein (α1AGP), and haptoglobin (Hp), the main constituents of α-globulin and which belong to acute phase proteins, on NK activity were examined using K562 cells as the NK target cells. Among the three proteins, α1,-AT and α1AGP had inhibitory effects on NK activity for "fast target" K562 cells. The α,-AT preparations having the same protein concentration and a different trypsin inhibitory capacity (TIC) had an equal effect. Although α1AT and α1,-AGP equally reduced the NK activity, the mechanism involved in the reduction differed, in that the effect of α1,-AT directed toward NK cells reduced their binding capacity with the target cells, α1,-AGP probably interacts with a cytotoxic factor secreted from NK cells following effector-target interaction. These studies suggest that each of the acute-phase proteins, which increase following inflammation, inhibits NK cell function by two distinct mechanisms.
AB - The effects of α1-antitrypsin (α1,-AT), α1,-acid glycoprotein (α1AGP), and haptoglobin (Hp), the main constituents of α-globulin and which belong to acute phase proteins, on NK activity were examined using K562 cells as the NK target cells. Among the three proteins, α1,-AT and α1AGP had inhibitory effects on NK activity for "fast target" K562 cells. The α,-AT preparations having the same protein concentration and a different trypsin inhibitory capacity (TIC) had an equal effect. Although α1AT and α1,-AGP equally reduced the NK activity, the mechanism involved in the reduction differed, in that the effect of α1,-AT directed toward NK cells reduced their binding capacity with the target cells, α1,-AGP probably interacts with a cytotoxic factor secreted from NK cells following effector-target interaction. These studies suggest that each of the acute-phase proteins, which increase following inflammation, inhibits NK cell function by two distinct mechanisms.
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U2 - 10.1007/BF00917593
DO - 10.1007/BF00917593
M3 - Article
C2 - 3874163
AN - SCOPUS:0021834103
SN - 0360-3997
VL - 9
SP - 211
EP - 219
JO - Inflammation
JF - Inflammation
IS - 2
ER -