Influence of acute-phase proteins on the activity of natural killer cells

Yuzo Okumura, Jiro Kudo, Tohru Ikuta, Satoshi Kurokawa, Hiromi Ishibashi, Hideo Okubo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of α1-antitrypsin (α1,-AT), α1,-acid glycoprotein (α1AGP), and haptoglobin (Hp), the main constituents of α-globulin and which belong to acute phase proteins, on NK activity were examined using K562 cells as the NK target cells. Among the three proteins, α1,-AT and α1AGP had inhibitory effects on NK activity for "fast target" K562 cells. The α,-AT preparations having the same protein concentration and a different trypsin inhibitory capacity (TIC) had an equal effect. Although α1AT and α1,-AGP equally reduced the NK activity, the mechanism involved in the reduction differed, in that the effect of α1,-AT directed toward NK cells reduced their binding capacity with the target cells, α1,-AGP probably interacts with a cytotoxic factor secreted from NK cells following effector-target interaction. These studies suggest that each of the acute-phase proteins, which increase following inflammation, inhibits NK cell function by two distinct mechanisms.

Original languageEnglish (US)
Pages (from-to)211-219
Number of pages9
JournalInflammation
Volume9
Issue number2
DOIs
StatePublished - Jun 1 1985
Externally publishedYes

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Acute-Phase Proteins
Natural Killer Cells
K562 Cells
Glycoproteins
Acids
Haptoglobins
Globulins
Trypsin
Proteins
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Okumura, Y., Kudo, J., Ikuta, T., Kurokawa, S., Ishibashi, H., & Okubo, H. (1985). Influence of acute-phase proteins on the activity of natural killer cells. Inflammation, 9(2), 211-219. https://doi.org/10.1007/BF00917593

Influence of acute-phase proteins on the activity of natural killer cells. / Okumura, Yuzo; Kudo, Jiro; Ikuta, Tohru; Kurokawa, Satoshi; Ishibashi, Hiromi; Okubo, Hideo.

In: Inflammation, Vol. 9, No. 2, 01.06.1985, p. 211-219.

Research output: Contribution to journalArticle

Okumura, Y, Kudo, J, Ikuta, T, Kurokawa, S, Ishibashi, H & Okubo, H 1985, 'Influence of acute-phase proteins on the activity of natural killer cells', Inflammation, vol. 9, no. 2, pp. 211-219. https://doi.org/10.1007/BF00917593
Okumura, Yuzo ; Kudo, Jiro ; Ikuta, Tohru ; Kurokawa, Satoshi ; Ishibashi, Hiromi ; Okubo, Hideo. / Influence of acute-phase proteins on the activity of natural killer cells. In: Inflammation. 1985 ; Vol. 9, No. 2. pp. 211-219.
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