Influence of basal androgen levels in euandrogenic women on glucose homeostasis

D. Grainger, R. DeFronzo, K. Thornton, R. Sherwin, G. Rossi, Michael Peter Diamond, M. Connoly-Diamond

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To evaluate possible relationships between insulin action and the normal variations of serum androgens in euandrogenic women. Design: Prospective evaluation of insulin action in normal nonobese women using hyperglycemic and euglycemic hyperinsulinemic clamp techniques, correlating insulin action to serum testosterone (T), free T, androstenedione (A), and dehydroepiandrosterone sulfate (DHEAS). Statistical analysis used Spearman's rank correlation. Setting: Yale University Clinical Research Center. Participants: Nonobese females with normal oral glucose tolerance tests, on no medications known to affect glucose metabolism, having the following range of serum androgen levels: T, 0.69 to 3.12 nmol/L; free T, 0.17 to 1.25 nmol/L; A, 2.48 to 11.31 nmol/L; DHEAS, 0.68 to 10.61 μmol/L. Total number of patients studied: hyperglycemic clamps, n = 58; euglycemic hyperinsulinemic clamps, n = 43. Interventions: None. Main Outcome Measures: Pancreatic insulin secretion in response to hyperglycemia and insulin action as assessed by insulin-mediated glucose utilization using the euglycemic, hyperinsulinemic clamp technique. Results: We identified no significant correlation between serum androgens and either glucose uptake or insulin- mediated glucose utilization. Glucose-stimulated insulin release was negatively correlated with serum T and free T throughout the normal range of these hormones. Conclusion: We conclude that, within the normal range, variations of serum androgens are not correlated with changes in the response to insulin. It seems unlikely, therefore, that modest increases of serum androgens within the normal range are responsible for inducing insulin resistance.

Original languageEnglish (US)
Pages (from-to)1113-1118
Number of pages6
JournalFertility and sterility
Volume58
Issue number6
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Androgens
Homeostasis
Insulin
Glucose
Glucose Clamp Technique
Serum
Dehydroepiandrosterone Sulfate
Reference Values
Androstenedione
Glucose Tolerance Test
Hyperglycemia
Insulin Resistance
Testosterone
Outcome Assessment (Health Care)
Hormones
Research

Keywords

  • Insulin resistance
  • hyperandrogenism
  • polycystic ovarian syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Grainger, D., DeFronzo, R., Thornton, K., Sherwin, R., Rossi, G., Diamond, M. P., & Connoly-Diamond, M. (1992). Influence of basal androgen levels in euandrogenic women on glucose homeostasis. Fertility and sterility, 58(6), 1113-1118.

Influence of basal androgen levels in euandrogenic women on glucose homeostasis. / Grainger, D.; DeFronzo, R.; Thornton, K.; Sherwin, R.; Rossi, G.; Diamond, Michael Peter; Connoly-Diamond, M.

In: Fertility and sterility, Vol. 58, No. 6, 01.01.1992, p. 1113-1118.

Research output: Contribution to journalArticle

Grainger, D, DeFronzo, R, Thornton, K, Sherwin, R, Rossi, G, Diamond, MP & Connoly-Diamond, M 1992, 'Influence of basal androgen levels in euandrogenic women on glucose homeostasis', Fertility and sterility, vol. 58, no. 6, pp. 1113-1118.
Grainger D, DeFronzo R, Thornton K, Sherwin R, Rossi G, Diamond MP et al. Influence of basal androgen levels in euandrogenic women on glucose homeostasis. Fertility and sterility. 1992 Jan 1;58(6):1113-1118.
Grainger, D. ; DeFronzo, R. ; Thornton, K. ; Sherwin, R. ; Rossi, G. ; Diamond, Michael Peter ; Connoly-Diamond, M. / Influence of basal androgen levels in euandrogenic women on glucose homeostasis. In: Fertility and sterility. 1992 ; Vol. 58, No. 6. pp. 1113-1118.
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abstract = "Objective: To evaluate possible relationships between insulin action and the normal variations of serum androgens in euandrogenic women. Design: Prospective evaluation of insulin action in normal nonobese women using hyperglycemic and euglycemic hyperinsulinemic clamp techniques, correlating insulin action to serum testosterone (T), free T, androstenedione (A), and dehydroepiandrosterone sulfate (DHEAS). Statistical analysis used Spearman's rank correlation. Setting: Yale University Clinical Research Center. Participants: Nonobese females with normal oral glucose tolerance tests, on no medications known to affect glucose metabolism, having the following range of serum androgen levels: T, 0.69 to 3.12 nmol/L; free T, 0.17 to 1.25 nmol/L; A, 2.48 to 11.31 nmol/L; DHEAS, 0.68 to 10.61 μmol/L. Total number of patients studied: hyperglycemic clamps, n = 58; euglycemic hyperinsulinemic clamps, n = 43. Interventions: None. Main Outcome Measures: Pancreatic insulin secretion in response to hyperglycemia and insulin action as assessed by insulin-mediated glucose utilization using the euglycemic, hyperinsulinemic clamp technique. Results: We identified no significant correlation between serum androgens and either glucose uptake or insulin- mediated glucose utilization. Glucose-stimulated insulin release was negatively correlated with serum T and free T throughout the normal range of these hormones. Conclusion: We conclude that, within the normal range, variations of serum androgens are not correlated with changes in the response to insulin. It seems unlikely, therefore, that modest increases of serum androgens within the normal range are responsible for inducing insulin resistance.",
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