Influence of clindamycin on fibronectin-staphylococcal interactions

J. E. Doran, J. P. Rissing

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

This report examines the effects of subinhibitory concentrations of clindamycin on fibronectin-staphylococcal interactions. Using in-vitro binding assays, exposure of staphylococci to subinhibitory concentrations of clindamycin results in a dose-dependent decrease in fibronectin's ability to bind to treated organisms. Concomitant with decreased fibronectin binding is a decreased ability for fibronectin to mediate the phagocytosis of treated organisms by human polymorphonuclear leukocytes. Serum-mediated phagocytosis of clindamycin-treated organisms remained effective despite the reduction in fibronectin binding capabilities. These results suggest that the clinical use of clindamycin has the potential to affect bacterial binding of fibronectin, thus modifying the adherence of organisms to host surfaces without adversely effecting their clearance by the reticuloendothelial system.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalJournal of Antimicrobial Chemotherapy
Volume12
Issue numberSUPPL. C
StatePublished - Dec 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

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