Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: An experimental study in the dog

Andreas Stavropoulos, Ulf M E Wikesjö

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20 Citations (Scopus)

Abstract

Objective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration. Material and Methods: Contra-lateral one-wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval. Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5% versus 65% and the bone biomaterial 11.6% versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare. Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.

Original languageEnglish (US)
Pages (from-to)534-543
Number of pages10
JournalJournal of Clinical Periodontology
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2010

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Guided Tissue Regeneration
Biocompatible Materials
Wound Healing
Bone Matrix
Regeneration
Collagen
Dogs
Bone and Bones
Periodontal Ligament
Root Resorption
Newfoundland and Labrador
Dental Cementum
Ankylosis
Osteogenesis
Membranes

Keywords

  • Animal
  • Bovine bone biomaterial
  • Guided tissue regeneration
  • Membrane
  • Periodontal regeneration
  • Pre-clinical

ASJC Scopus subject areas

  • Periodontics

Cite this

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title = "Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: An experimental study in the dog",
abstract = "Objective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration. Material and Methods: Contra-lateral one-wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval. Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5{\%} versus 65{\%} and the bone biomaterial 11.6{\%} versus 13.1{\%} of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare. Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.",
keywords = "Animal, Bovine bone biomaterial, Guided tissue regeneration, Membrane, Periodontal regeneration, Pre-clinical",
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T1 - Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration

T2 - An experimental study in the dog

AU - Stavropoulos, Andreas

AU - Wikesjö, Ulf M E

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Objective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration. Material and Methods: Contra-lateral one-wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval. Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5% versus 65% and the bone biomaterial 11.6% versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare. Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.

AB - Objective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration. Material and Methods: Contra-lateral one-wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval. Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5% versus 65% and the bone biomaterial 11.6% versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare. Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.

KW - Animal

KW - Bovine bone biomaterial

KW - Guided tissue regeneration

KW - Membrane

KW - Periodontal regeneration

KW - Pre-clinical

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