Influence of dehydroepiandrosterone on rabbit intraocular pressure

E. Claire Kearse, Orinthal L. Mcintyre, Maribeth H Johnson, Calbert I. Phillips, Richard Lathe, William Adams, Keith Green

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The systemic concentration of dehydroepiandrosterone decreases with age in primates while in humans intraocular pressure (IOP) increases with aging. This study was designed to investigate if a relationship existed between dehydroepiandrosterone and IOP in pigmented rabbits. Methods: Animals were treated unilaterally for 6 weeks with topical 3% dehydroepiandrosterone in 30% 2-hydroxypropyl-beta-cyclodextrin; the contralateral eye received vehicle alone. Drops were applied, and IOP measured, twice daily. Results: Small, but statistically significant, drug-related effects were found. IOP was consistently higher in the afternoon; the afternoon minus morning difference in IOP, however, decreased with time. Topical, radioactive drug application indicated very low level penetration into aqueous humor, iris, corneal epithelium, the rest of the cornea, or bulbar conjunctiva. Conclusion: The small drug-related effects may be due, in large part, to poor intraocular drug penetration. The circadian rhythm of IOP appears to be time-dependent in chronic studies with a gradual loss of IOP difference between a.m. and p.m. readings. Copyright (C) 2001 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalOphthalmic Research
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2001

Fingerprint

Dehydroepiandrosterone
Intraocular Pressure
Rabbits
Pharmaceutical Preparations
Corneal Epithelium
Aqueous Humor
Conjunctiva
Iris
Circadian Rhythm
Cornea
Primates
Reading

Keywords

  • Circadian rhythm
  • Cyclodextrin Pigmented rabbit
  • Dehydroepiandrosterone
  • Intraocular drug distribution
  • Intraocular pressure
  • Topical drop

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Kearse, E. C., Mcintyre, O. L., Johnson, M. H., Phillips, C. I., Lathe, R., Adams, W., & Green, K. (2001). Influence of dehydroepiandrosterone on rabbit intraocular pressure. Ophthalmic Research, 33(1), 42-47. https://doi.org/10.1159/000055640

Influence of dehydroepiandrosterone on rabbit intraocular pressure. / Kearse, E. Claire; Mcintyre, Orinthal L.; Johnson, Maribeth H; Phillips, Calbert I.; Lathe, Richard; Adams, William; Green, Keith.

In: Ophthalmic Research, Vol. 33, No. 1, 01.01.2001, p. 42-47.

Research output: Contribution to journalArticle

Kearse, EC, Mcintyre, OL, Johnson, MH, Phillips, CI, Lathe, R, Adams, W & Green, K 2001, 'Influence of dehydroepiandrosterone on rabbit intraocular pressure', Ophthalmic Research, vol. 33, no. 1, pp. 42-47. https://doi.org/10.1159/000055640
Kearse EC, Mcintyre OL, Johnson MH, Phillips CI, Lathe R, Adams W et al. Influence of dehydroepiandrosterone on rabbit intraocular pressure. Ophthalmic Research. 2001 Jan 1;33(1):42-47. https://doi.org/10.1159/000055640
Kearse, E. Claire ; Mcintyre, Orinthal L. ; Johnson, Maribeth H ; Phillips, Calbert I. ; Lathe, Richard ; Adams, William ; Green, Keith. / Influence of dehydroepiandrosterone on rabbit intraocular pressure. In: Ophthalmic Research. 2001 ; Vol. 33, No. 1. pp. 42-47.
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