Influence of dehydroepiandrosterone on rabbit intraocular pressure

E. Claire Kearse, Orinthal L. Mcintyre, Maribeth H. Johnson, Calbert I. Phillips, Richard Lathe, William Adams, Keith Green

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Purpose: The systemic concentration of dehydroepiandrosterone decreases with age in primates while in humans intraocular pressure (IOP) increases with aging. This study was designed to investigate if a relationship existed between dehydroepiandrosterone and IOP in pigmented rabbits. Methods: Animals were treated unilaterally for 6 weeks with topical 3% dehydroepiandrosterone in 30% 2-hydroxypropyl-beta-cyclodextrin; the contralateral eye received vehicle alone. Drops were applied, and IOP measured, twice daily. Results: Small, but statistically significant, drug-related effects were found. IOP was consistently higher in the afternoon; the afternoon minus morning difference in IOP, however, decreased with time. Topical, radioactive drug application indicated very low level penetration into aqueous humor, iris, corneal epithelium, the rest of the cornea, or bulbar conjunctiva. Conclusion: The small drug-related effects may be due, in large part, to poor intraocular drug penetration. The circadian rhythm of IOP appears to be time-dependent in chronic studies with a gradual loss of IOP difference between a.m. and p.m. readings. Copyright (C) 2001 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalOphthalmic Research
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Circadian rhythm
  • Cyclodextrin Pigmented rabbit
  • Dehydroepiandrosterone
  • Intraocular drug distribution
  • Intraocular pressure
  • Topical drop

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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  • Cite this

    Kearse, E. C., Mcintyre, O. L., Johnson, M. H., Phillips, C. I., Lathe, R., Adams, W., & Green, K. (2001). Influence of dehydroepiandrosterone on rabbit intraocular pressure. Ophthalmic Research, 33(1), 42-47. https://doi.org/10.1159/000055640