Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats

David L. Mattson, Mary Pat Kunert, Mary L. Kaldunski, Andrew S. Greene, Richard J. Roman, Howard J. Jacob, Allen W. Cowley

Research output: Contribution to journalArticle

Abstract

Experiments examined the influence of diet and genetics on hypertension and renal disease in inbred Dahl salt-sensitive (SS/Mcw) rats and consomic rats in which chromosomes 16 (SS.BN16) or 18 (SS.BN18) of the normotensive Brown Norway rat were inserted into the genetic background of the SS/Mcw. Dahl SS/Mcw breeders and offspring were randomly placed on a purified AIN-76A diet or a grain-based diet, and male offspring were screened for cardiovascular and renal phenotypes following 3 wk on a 4.0% NaCl diet. High-salt arterial blood pressure (162 ± 5 mmHg, n = 10), urinary protein excretion (147 ± 16 mg/day, n = 14), and albumin excretion (72 ± 9 mg/day, n = 14) were significantly elevated in the Dahl SS/Mcw maintained on the purified diet compared with rats fed the grain-based diet. Rats fed the purified diet also exhibited significantly more renal glomerular and tubular damage than rats fed the grain diet. Moreover, feeding the purified diet to the parents led to a significant increase in blood pressure in the offspring, regardless of offspring diet. Similar dietary effects were observed in SS.BN16 and SS.BN18 rats. In rats fed the purified diet, substitution of chromosomes 16 or 18 led to a significant decrease in arterial blood pressure, albumin excretion, and protein excretion compared with the SS/Mcw. Chromosomal substitution did not, however, affect albumin or protein excretion in the consomic rats compared with the SS/Mcw when the rats were maintained on the grain diet. These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat.

Original languageEnglish (US)
Pages (from-to)194-203
Number of pages10
JournalPhysiological Genomics
Volume16
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Fingerprint

Inbred Dahl Rats
Renal Hypertension
Diet
Chromosomes, Human, Pair 16
Albumins
Salts
Arterial Pressure
Kidney
Chromosomes, Human, Pair 18
Proteins

Keywords

  • Blood pressure
  • Consomic
  • Sodium-dependent hypertension

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Mattson, D. L., Kunert, M. P., Kaldunski, M. L., Greene, A. S., Roman, R. J., Jacob, H. J., & Cowley, A. W. (2004). Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. Physiological Genomics, 16, 194-203. https://doi.org/10.1152/physiolgenomics.00151.2003

Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. / Mattson, David L.; Kunert, Mary Pat; Kaldunski, Mary L.; Greene, Andrew S.; Roman, Richard J.; Jacob, Howard J.; Cowley, Allen W.

In: Physiological Genomics, Vol. 16, 01.04.2004, p. 194-203.

Research output: Contribution to journalArticle

Mattson, DL, Kunert, MP, Kaldunski, ML, Greene, AS, Roman, RJ, Jacob, HJ & Cowley, AW 2004, 'Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats', Physiological Genomics, vol. 16, pp. 194-203. https://doi.org/10.1152/physiolgenomics.00151.2003
Mattson, David L. ; Kunert, Mary Pat ; Kaldunski, Mary L. ; Greene, Andrew S. ; Roman, Richard J. ; Jacob, Howard J. ; Cowley, Allen W. / Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. In: Physiological Genomics. 2004 ; Vol. 16. pp. 194-203.
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