Influence of Gastric Emptying and Gut Transit Testing on Clinical Management Decisions in Suspected Gastroparesis

William L. Hasler, Satish S.C. Rao, Richard W. McCallum, Richard A. Krause, Linda A. Nguyen, Michael I. Schulman, Allen A. Lee, Baharak Moshiree, John M. Wo, Henry P. Parkman, Irene Sarosiek, Gregory E. Wilding, Braden Kuo

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Gastric emptying scintigraphy (GES) or wireless motility capsules (WMCs) can evaluate upper gastrointestinal symptoms in suspected gastroparesis; WMC tests can also investigate lower gut symptoms. We aimed to determine whether these tests impact treatment plans and needs for additional diagnostic evaluation. METHODS: In a prospective, multicenter study, 150 patients with gastroparesis symptoms simultaneously underwent GES and WMC testing. Based on these results, investigators devised management plans to recommend changes in medications, diet, and surgical therapies and order additional diagnostic tests. RESULTS: Treatment changes were recommended more often based on the WMC vs GES results (68% vs 48%) (P < 0.0001). Ordering of additional test(s) was eliminated more often with WMC vs GES (71% vs 31%) (P < 0.0001). Prokinetics (P = 0.0007) and laxatives (P < 0.0001) were recommended more often based on the WMC vs GES results. Recommendations for prokinetics and gastroparesis diets were higher and neuromodulators lower in subjects with delayed emptying on both tests (all P ≤ 0.0006). Laxatives and additional motility tests were ordered more frequently for delayed compared with normal WMC colonic transit (P ≤ 0.02). Multiple motility tests were ordered more often on the basis of GES vs WMC findings (P ≤ 0.004). Antidumping diets and transit slowing medications were more commonly recommended for rapid WMC gastric emptying (P ≤ 0.03). DISCUSSION: WMC transit results promote medication changes and eliminate additional diagnostic testing more often than GES because of greater detection of delayed gastric emptying and profiling the entire gastrointestinal tract in patients with gastroparesis symptoms. TRANSLATIONAL IMPACT: Gastric scintigraphy and WMCs have differential impact on management decisions in suspected gastroparesis.

Original languageEnglish (US)
Pages (from-to)e00084
JournalClinical and translational gastroenterology
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2019
Externally publishedYes

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Gastroparesis
Gastric Emptying
Capsules
Radionuclide Imaging
Laxatives
Diet
Diet Therapy
Routine Diagnostic Tests
Multicenter Studies
Neurotransmitter Agents
Gastrointestinal Tract
Stomach

ASJC Scopus subject areas

  • Gastroenterology

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Influence of Gastric Emptying and Gut Transit Testing on Clinical Management Decisions in Suspected Gastroparesis. / Hasler, William L.; Rao, Satish S.C.; McCallum, Richard W.; Krause, Richard A.; Nguyen, Linda A.; Schulman, Michael I.; Lee, Allen A.; Moshiree, Baharak; Wo, John M.; Parkman, Henry P.; Sarosiek, Irene; Wilding, Gregory E.; Kuo, Braden.

In: Clinical and translational gastroenterology, Vol. 10, No. 10, 01.10.2019, p. e00084.

Research output: Contribution to journalArticle

Hasler, WL, Rao, SSC, McCallum, RW, Krause, RA, Nguyen, LA, Schulman, MI, Lee, AA, Moshiree, B, Wo, JM, Parkman, HP, Sarosiek, I, Wilding, GE & Kuo, B 2019, 'Influence of Gastric Emptying and Gut Transit Testing on Clinical Management Decisions in Suspected Gastroparesis', Clinical and translational gastroenterology, vol. 10, no. 10, pp. e00084. https://doi.org/10.14309/ctg.0000000000000084
Hasler, William L. ; Rao, Satish S.C. ; McCallum, Richard W. ; Krause, Richard A. ; Nguyen, Linda A. ; Schulman, Michael I. ; Lee, Allen A. ; Moshiree, Baharak ; Wo, John M. ; Parkman, Henry P. ; Sarosiek, Irene ; Wilding, Gregory E. ; Kuo, Braden. / Influence of Gastric Emptying and Gut Transit Testing on Clinical Management Decisions in Suspected Gastroparesis. In: Clinical and translational gastroenterology. 2019 ; Vol. 10, No. 10. pp. e00084.
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AU - Nguyen, Linda A.

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AU - Lee, Allen A.

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