Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women

E. M. Brooks-Asplund, J. G. Cannon, W. L. Kenney

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Postmenopausal women receiving estrogen-replacement therapy (ERT) regulate body temperature (T(b)) at a lower level than women not receiving hormone replacement therapy (untreated) and women using estrogen plus progesterone therapy (E + P), but it is not clear if reproductive hormones alter T(b) by directly acting on central thermoregulatory centers or indirectly via a secondary mediator(s). The purpose of the present investigation was to examine the possible involvement of pyrogenic cytokines and cyclooxygenase (COX) products (e.g., prostaglandins) in the regulation of T(b) in three groups of postmenopausal women (8 ERT, 7 E + P, and 8 untreated). We measured ex vivo secretion of cytokine agonists [tumor necrosis factor (TNF)-α and interleukin (IL)-1β and -6] and modifiers (IL-2 soluble receptor, IL-1 receptor antagonist, soluble TNF receptor type I, soluble TNF receptor type II, soluble IL-6 receptor, and soluble glycoprotein 130) from peripheral blood mononuclear cells and thermoregulatory responses at rest and during 1 h of passive whole body heating in the postmenopausal women before and after 3 days of placebo or aspirin (50 mg · day-1 · kg-1). With and without aspirin, the ERT group had a lower baseline rectal temperature (T(re); 0.44°C, P < 0.004) and a reduced T(b) threshold for cutaneous vasodilation (0.29°C and 0.38°C, P < 0.01) compared with the untreated and E + P groups, respectively. In the placebo condition, waking morning oral temperature (T(or)) correlated with ex vivo secretion of the proteins associated with IL-6 bioactivity. Aspirin caused significant reductions in waking T(or) in the E + P group and in baseline T(re) in the untreated group. However, the difference in thermoregulation brought about by steroid hormone treatment could not be explained by these relatively modest apparent influences by cytokines and COX products. Therefore, the altered thermoregulation induced by reproductive steroid therapy appears to occur via a mechanism distinct from a classic infection-induced fever.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number3 48-3
StatePublished - Oct 3 2000

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Hormone Replacement Therapy
Aspirin
Estrogen Replacement Therapy
Temperature
Body Temperature Regulation
Prostaglandin-Endoperoxide Synthases
Cytokines
Interleukin-6
Cytokine Receptor gp130
Steroids
Placebos
Hormones
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Interleukin-6 Receptors
Interleukin-1 Receptors
Interleukin-2 Receptors
Body Temperature
Interleukin-1
Vasodilation

Keywords

  • Cyclooxygenase
  • Cytokines
  • Estrogen
  • Progesterone
  • Reproductive hormones
  • Skin blood flow

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women. / Brooks-Asplund, E. M.; Cannon, J. G.; Kenney, W. L.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 279, No. 3 48-3, 03.10.2000.

Research output: Contribution to journalArticle

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