Influence of olsalazine on gastrointestinal transit in ulcerative colitis

S. S.C. Rao, N. W. Read, C. D. Holdswortii

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

the effect of olsalazine on stool output and the transit of a solid radiolabelled meal through the stomach, small intestine and colon was studied in six patients with ulcerative colitis intolerant of sulphasalazine. Olsalazine 250 mg four times daily significantly accelerated gastric emptying (mean±sd; 45·3±24·2 min v 67·3± 33·1 min, p<0·05), mouth to caecum transit time (242±41 min i, 325+33 min, p<0·02) and whole gut transit time (6(05±26 h v 37·8±17·8 h, P<0·05). No significant changes were seen in mean daily stool weight (215±41 g v 162±62 g) and Mean daily stool frequency (2·2±0·6 v 2·4± 1·8). None of these patients developed diarrhoea, but Acceleration of gastric and intestinal transit m'ay be responsible for the diarrhoea reported in some patients taking this drug.

Original languageEnglish (US)
Pages (from-to)1474-1477
Number of pages4
JournalGut
Volume28
Issue number11
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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