Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading

Arash Hanifi, Xiaohong Bi, Xu Yang, Beril Kavukcuoglu, Ping-Chang Lin, Edward Dicarlo, Richard G. Spencer, Mathias P.G. Bostrom, Nancy Pleshko

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Osteoarthritis (OA), a degenerative cartilage disease, results in alterations of the chemical and structural properties of tissue. Arthroscopic evaluation of full-depth tissue composition is limited and would require tissue harvesting, which is inappropriate in daily routine. Fourier transform infrared (FT-IR) spectroscopy is a modality based on molecular vibrations of matrix components that can be used in conjunction with fiber optics to acquire quantitative compositional data from the cartilage matrix. Purpose: To develop a model based on infrared spectra of articular cartilage to predict the histological Mankin score as an indicator of tissue quality. Study Design: Comparative laboratory study. Methods: Infrared fiber optic probe (IFOP) spectra were collected from nearly normal and more degraded regions of tibial plateau articular cartilage harvested during knee arthroplasty (N = 61). Each region was graded using a modified Mankin score. A multivariate partial least squares algorithm using second-derivative spectra was developed to predict the histological modified Mankin score. Results: The partial least squares model derived from IFOP spectra predicted the modified Mankin score with a prediction error of approximately 1.4, which resulted in approximately 72% of the Mankin-scored tissues being predicted correctly and 96% being predicted within 1 grade of their true score. Conclusion: These data demonstrate that IFOP spectral parameters correlate with histological tissue grade and can be used to provide information on tissue composition. Clinical Relevance: Infrared fiber optic probe studies have significant potential for the evaluation of cartilage tissue quality without the need for tissue harvest. Combined with arthroscopy, IFOP analysis could facilitate the definition of tissue margins in debridement procedures.

Original languageEnglish (US)
Pages (from-to)2853-2861
Number of pages9
JournalAmerican Journal of Sports Medicine
Volume40
Issue number12
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Fingerprint

Cartilage
Articular Cartilage
Least-Squares Analysis
Tissue and Organ Harvesting
Cartilage Diseases
Knee Replacement Arthroplasties
Arthroscopy
Debridement
Fourier Transform Infrared Spectroscopy
Vibration
Osteoarthritis

Keywords

  • Fourier transform infrared spectroscopy
  • arthroscopy
  • cartilage
  • histological score
  • osteoarthritis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hanifi, A., Bi, X., Yang, X., Kavukcuoglu, B., Lin, P-C., Dicarlo, E., ... Pleshko, N. (2012). Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading. American Journal of Sports Medicine, 40(12), 2853-2861. https://doi.org/10.1177/0363546512462009

Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading. / Hanifi, Arash; Bi, Xiaohong; Yang, Xu; Kavukcuoglu, Beril; Lin, Ping-Chang; Dicarlo, Edward; Spencer, Richard G.; Bostrom, Mathias P.G.; Pleshko, Nancy.

In: American Journal of Sports Medicine, Vol. 40, No. 12, 01.12.2012, p. 2853-2861.

Research output: Contribution to journalArticle

Hanifi, A, Bi, X, Yang, X, Kavukcuoglu, B, Lin, P-C, Dicarlo, E, Spencer, RG, Bostrom, MPG & Pleshko, N 2012, 'Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading', American Journal of Sports Medicine, vol. 40, no. 12, pp. 2853-2861. https://doi.org/10.1177/0363546512462009
Hanifi, Arash ; Bi, Xiaohong ; Yang, Xu ; Kavukcuoglu, Beril ; Lin, Ping-Chang ; Dicarlo, Edward ; Spencer, Richard G. ; Bostrom, Mathias P.G. ; Pleshko, Nancy. / Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading. In: American Journal of Sports Medicine. 2012 ; Vol. 40, No. 12. pp. 2853-2861.
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