Inhibiting effect of cytotoxic bromine-containing compounds from sponges (Aplysinidae) on Na+-K+-ATPase activity

B. A. Gorshkov, I. A. Gorshkova, T. N. Makarieva, V. A. Stonik

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

-The bromine-containing compounds from sponges of the Aplysinidae family inhibit, in vitro, the Na+-K+-ATPase activity of the rat brain microsomal fraction. The extent of inhibition is dependent on concentration and chemical structure of the compounds. The substances containing the dienone fragment, such as 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-acetamide (IV), 3,5-dibromo-1-acetoxy-4-oxo-2,5-cyclohexadien-1-acetonitrile (V) and 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-ethylacetate (VI), are powerful inhibitors of Na+-K+-ATPase.

Original languageEnglish (US)
Pages (from-to)1092-1094
Number of pages3
JournalToxicon
Volume20
Issue number6
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Toxicology

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