Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes

Shiow Chwen Tsai, Yu Chung Chiao, Chien Chen Lu, Ming Luen Doong, Yen Hao Chen, Hsi Chang Shih, Charlie Liaw, Shyi Wu Wang, Paulus S. Wang

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

1 The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3':5'-cyclic monophosphate (cyclic AMP) in rats was studied. 2 A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine. 3 Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone. 4 Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes. 5 These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production.

Original languageEnglish (US)
Pages (from-to)984-988
Number of pages5
JournalBritish Journal of Pharmacology
Volume118
Issue number4
DOIs
StatePublished - Jan 1 1996

Keywords

  • Amphetamine
  • Cyclic AMP
  • Human chorionic gonadotropin (hCG)
  • Rat testes
  • Testosterone

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Tsai, S. C., Chiao, Y. C., Lu, C. C., Doong, M. L., Chen, Y. H., Shih, H. C., Liaw, C., Wang, S. W., & Wang, P. S. (1996). Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes. British Journal of Pharmacology, 118(4), 984-988. https://doi.org/10.1111/j.1476-5381.1996.tb15496.x