Abstract
1 The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3':5'-cyclic monophosphate (cyclic AMP) in rats was studied. 2 A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine. 3 Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone. 4 Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes. 5 These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production.
Original language | English (US) |
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Pages (from-to) | 984-988 |
Number of pages | 5 |
Journal | British Journal of Pharmacology |
Volume | 118 |
Issue number | 4 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Amphetamine
- Cyclic AMP
- Human chorionic gonadotropin (hCG)
- Rat testes
- Testosterone
ASJC Scopus subject areas
- Pharmacology