Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes

Shiow Chwen Tsai, Yu Chung Chiao, Chien Chen Lu, Ming Luen Doong, Yen-Hao Chen, Hsi Chang Shih, Charlie Liaw, Shyi Wu Wang, Paulus S. Wang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

1 The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3':5'-cyclic monophosphate (cyclic AMP) in rats was studied. 2 A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine. 3 Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone. 4 Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes. 5 These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production.

Original languageEnglish (US)
Pages (from-to)984-988
Number of pages5
JournalBritish Journal of Pharmacology
Volume118
Issue number4
DOIs
StatePublished - Jan 1 1996

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Amphetamine
Cyclic AMP
Testosterone
Testis
Chorionic Gonadotropin
Intravenous Injections
Adenosine
Injections

Keywords

  • Amphetamine
  • Cyclic AMP
  • Human chorionic gonadotropin (hCG)
  • Rat testes
  • Testosterone

ASJC Scopus subject areas

  • Pharmacology

Cite this

Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes. / Tsai, Shiow Chwen; Chiao, Yu Chung; Lu, Chien Chen; Doong, Ming Luen; Chen, Yen-Hao; Shih, Hsi Chang; Liaw, Charlie; Wang, Shyi Wu; Wang, Paulus S.

In: British Journal of Pharmacology, Vol. 118, No. 4, 01.01.1996, p. 984-988.

Research output: Contribution to journalArticle

Tsai, Shiow Chwen ; Chiao, Yu Chung ; Lu, Chien Chen ; Doong, Ming Luen ; Chen, Yen-Hao ; Shih, Hsi Chang ; Liaw, Charlie ; Wang, Shyi Wu ; Wang, Paulus S. / Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes. In: British Journal of Pharmacology. 1996 ; Vol. 118, No. 4. pp. 984-988.
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