Inhibition by (-)-Persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes

Oe Kyung Kim; Akira Murakami; Yoshimasa Nakamura; Ha Won Kim; Hajime Ohigashi

doi:10.1271/bbb.64.2500

Inhibition by (-)-Persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes

Oe Kyung Kim, Akira Murakami, Yoshimasa Nakamura, Ha Won Kim, Hajime Ohigashi

Cardiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O₂⁻) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O₂⁻ generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.

Original language	English (US)
Pages (from-to)	2500-2503
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	64
Issue number	11
DOIs	https://doi.org/10.1271/bbb.64.2500
State	Published - 2000

Keywords

Nitric oxide
Persenone A
Superoxide

ASJC Scopus subject areas

General Medicine

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10.1271/bbb.64.2500

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abstract = "We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O2−) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O2− generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.",

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AU - Kim, Oe Kyung

AU - Murakami, Akira

AU - Nakamura, Yoshimasa

AU - Kim, Ha Won

AU - Ohigashi, Hajime

PY - 2000

Y1 - 2000

N2 - We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O2−) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O2− generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.

AB - We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O2−) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O2− generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.

KW - Nitric oxide

KW - Persenone A

KW - Superoxide

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 11

ER -

Inhibition by (-)-Persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes

Abstract

Keywords

ASJC Scopus subject areas

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