Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus

Jimok Kim, Bradley E. Alger

Research output: Contribution to journalArticle

187 Scopus citations

Abstract

In hippocampal pyramidal cells, a rise in Ca2+ releases endocannabinoids that activate the presynaptic cannabinoid receptor (CB1R) and transiently reduce GABAergic transmission-a process called depolarization- induced suppression of inhibition (DSI). The mechanism that limits the duration of endocannabinoid action in intact cells is unknown. Here we show that inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggesting that COX-2 limits endocannabinoid action.

Original languageEnglish (US)
Pages (from-to)697-698
Number of pages2
JournalNature Neuroscience
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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