Inhibition of Friend virus (FVP)-induced murine erythropoiesis with prostaglandin (PGF2α): potentiation and inhibition of erythropoietin and prevention of both with PGD2

J. P. Lewis, Russell R Moores, W. A. Neal, F. A. Garver, C. L. Lutcher, J. R. Zucali, E. A. Mirand

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5 Scopus citations

Abstract

An erythropoietin-independent virus-induced murine erythroleukemia (FVP) is used to compare the effects of an erythropoiesis inhibitory factor (EIF) isolated from human urine with the effects of prostaglandin F2α. The consequent inhibition of FVP-induced erythropoiesis suggests that EIF and PGF2α have similar effects on the FVP-induced erythropoiesis in mice, and the effect of PGF2α is indirect. The similarity of the actions of EIF and PGF2α may indicate a potential role for prostaglandins in the physiological control of some types of erythrocytosis.

Original languageEnglish (US)
Pages (from-to)540-549
Number of pages10
JournalExperimental Hematology
Volume9
Issue number5
StatePublished - Jul 20 1981

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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    Lewis, J. P., Moores, R. R., Neal, W. A., Garver, F. A., Lutcher, C. L., Zucali, J. R., & Mirand, E. A. (1981). Inhibition of Friend virus (FVP)-induced murine erythropoiesis with prostaglandin (PGF2α): potentiation and inhibition of erythropoietin and prevention of both with PGD2. Experimental Hematology, 9(5), 540-549.