Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata

Irina A. Gorshkova, Boris A. Gorshkov, Sergey A. Fedoreev, Olga P. Shestak, Vyacheslav L. Novikov, Valentin A. Stonik

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata, was found to be a powerful inhibitor of the rat brainstem and of the rat brain cortex Na+, K+-ATPases and the rabbit muscle sarcoplasmic reticulum Ca2+-ATPase with I50 values of 7.0 x 10-7, 1.3 x 10-6 and 2.5 x 10-6 M, respectively. Halenaquinol also inhibited K+-phosphatase activity of the rat brain cortex Na+, K+-ATPase with an I50 value of 3 x 10-6 M. Ouabain-insensitive Mg2+-ATPase activity of the microsomal fraction of the rat brain cortex was weakly inhibited by halenaquinol. Inhibition was irreversible, dose- and time-dependent. Naphthohydroquinone fragment in structures of halenaquinol, related natural and model compounds was very important for an inhibiting effect.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalComparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volume122
Issue number1
DOIs
StatePublished - Jan 1 1999

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Keywords

  • Ca2-ATPase
  • Halenaquinol
  • Inhibition
  • K-ATPase
  • Marine organisms
  • Na
  • Petrosia seriata
  • Rat brain
  • Sarcoplasmic reticulum
  • Sponge natural products

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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