Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage

D. Chepurnova, V. Samoilova, D. Verin, A. G. Fesenko, Anisimov, A. A. Korotaeva

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Pulmonary edema is the major factor of tissue hypoxia in acute lung injury. Disruption of cell—cell contacts and lung interstitium increases permeability of the vascular endothelium and alveolar epithelium, which leads to the development of pulmonary edema. Meprin metalloproteases cleave extracellular matrix proteins, thus aggravating pulmonary edema. Meprin inhibitor actinonin was administered to rats with LPS-induced acute lung injury. Damaged lungs looked spotted and had multiple hemorrhage focuses, protein concentration in lavage fluid was increased, and lung weight coefficient was high. Administration of meprin inhibitor actinonin considerably reduced protein content in the bronchoalvelolar lavage and lung coefficient; only solitary lung hemorrhages were seen after this treatment. Thus, inhibition of meprins potentially alleviates LPS-induced disorders in the lung tissue permeability and reduces pulmonary edema.

Original languageEnglish (US)
Pages (from-to)719-721
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume166
Issue number6
DOIs
StatePublished - Apr 15 2019

Keywords

  • acute pulmonary damage
  • extracellular matrix
  • meprins
  • vascular permeability

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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