Inhibitory actions of serotonin on vascular smooth muscle

F. S. Lamb, R Clinton Webb

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a potent vasoactive agent possessing both constrictor and dilator properties. The vasoconstrictor properties of the monoamine include activation of serotonergic and adrenergic receptors on smooth muscle cells and an ability to amplify contractile responses to other agents. The vasodilator effects of serotonin, which are the focus of this review, are complex and include; (a) direct inhibition of vascular smooth muscle contraction; (b) inhibition of adrenergic neurotransmission; (c) enhanced release of the endothelium-derived relaxant factor (EDRF) and; (d) release of other vasodilator substances such as vasoactive intestinal polypeptide. In the intact animal responses to serotonin may be mediated by a combination of the compound's peripheral and central nervous system actions.

Original languageEnglish (US)
Pages (from-to)45-56
Number of pages12
JournalFernstrom Foundation Series
Volume10
StatePublished - Jan 1 1987
Externally publishedYes

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Vascular Smooth Muscle
Muscle
Serotonin
Vasodilator Agents
Endothelium-Dependent Relaxing Factors
Vasoactive Intestinal Peptide
Peripheral Nervous System
Neurology
Vasoconstrictor Agents
Muscle Contraction
Synaptic Transmission
Adrenergic Agents
Adrenergic Receptors
Smooth Muscle Myocytes
Animals
Central Nervous System
Chemical activation
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inhibitory actions of serotonin on vascular smooth muscle. / Lamb, F. S.; Webb, R Clinton.

In: Fernstrom Foundation Series, Vol. 10, 01.01.1987, p. 45-56.

Research output: Contribution to journalArticle

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