Initial experience with bendamustine in patients with recurrent primary central nervous system lymphoma: A case report

Jaclyn J. Renfrow, Alisha DeTroye, Michael Chan, Stephen Tatter, Thomas Ellis, Kevin McMullen, Annette Johnson, Ryan Mott, Glenn J. Lesser

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Novel therapeutic options for patients with recurrent primary central nervous system lymphoma (RPCNSL) are needed. Bendamustine, a bifunctional purine analog/alkylating agent, is approved for use in patients with progressive systemic indolent non-Hodgkin's B-cell lymphomas. Limited data suggests that bendamustine may partition into the brain in the setting of a disrupted blood-brain barrier. This report describes the first known experience of patients with RPCNSL treated with bendamustine. Therapy was well-tolerated and best response was noted as stable disease after eight cycles of bendamustine followed by a subsequent local systemic recurrence found at five months follow-up. CNS involvement in this patient remained stable 20 + months post-bendamustine treatment. Based on our observations, further neuropharmacokinetic and efficacy studies with bendamustine may be warranted in this patient population.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalJournal of Neuro-Oncology
Volume107
Issue number3
DOIs
StatePublished - May 1 2012
Externally publishedYes

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Keywords

  • Bendamustine
  • Chemotherapy
  • Recurrent primary CNS lymphoma

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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