Inorganic-organic nanocomposite assembly using collagen as a template and sodium tripolyphosphate as a biomimetic analog of matrix phosphoprotein

Lin Dai, Yi Pin Qi, Li Na Niu, Yan Liu, Cesar R. Pucci, Stephen Warwick Looney, Jun Qi Ling, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nanoprecursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.

Original languageEnglish (US)
Pages (from-to)3504-3511
Number of pages8
JournalCrystal Growth and Design
Volume11
Issue number8
DOIs
StatePublished - Aug 3 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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