Inorganic-organic nanocomposite assembly using collagen as a template and sodium tripolyphosphate as a biomimetic analog of matrix phosphoprotein

Lin Dai, Yi Pin Qi, Li Na Niu, Yan Liu, Cesar R. Pucci, Stephen Warwick Looney, Jun Qi Ling, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nanoprecursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.

Original languageEnglish (US)
Pages (from-to)3504-3511
Number of pages8
JournalCrystal Growth and Design
Volume11
Issue number8
DOIs
StatePublished - Aug 3 2011

Fingerprint

Phosphoproteins
biomimetics
Biomimetics
Apatites
collagens
Collagen
Nanocomposites
nanocomposites
templates
Apatite
assembly
apatites
Sodium
sodium
analogs
matrices
carbopol 940
Desorption
desorption
Polyphosphates

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Inorganic-organic nanocomposite assembly using collagen as a template and sodium tripolyphosphate as a biomimetic analog of matrix phosphoprotein. / Dai, Lin; Qi, Yi Pin; Niu, Li Na; Liu, Yan; Pucci, Cesar R.; Looney, Stephen Warwick; Ling, Jun Qi; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Crystal Growth and Design, Vol. 11, No. 8, 03.08.2011, p. 3504-3511.

Research output: Contribution to journalArticle

Dai, Lin ; Qi, Yi Pin ; Niu, Li Na ; Liu, Yan ; Pucci, Cesar R. ; Looney, Stephen Warwick ; Ling, Jun Qi ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Inorganic-organic nanocomposite assembly using collagen as a template and sodium tripolyphosphate as a biomimetic analog of matrix phosphoprotein. In: Crystal Growth and Design. 2011 ; Vol. 11, No. 8. pp. 3504-3511.
@article{3b70923fdb5242a4ba16b5264a8217f3,
title = "Inorganic-organic nanocomposite assembly using collagen as a template and sodium tripolyphosphate as a biomimetic analog of matrix phosphoprotein",
abstract = "Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nanoprecursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.",
author = "Lin Dai and Qi, {Yi Pin} and Niu, {Li Na} and Yan Liu and Pucci, {Cesar R.} and Looney, {Stephen Warwick} and Ling, {Jun Qi} and Pashley, {David Henry} and Tay, {Franklin Chi Meng}",
year = "2011",
month = "8",
day = "3",
doi = "10.1021/cg200663v",
language = "English (US)",
volume = "11",
pages = "3504--3511",
journal = "Crystal Growth and Design",
issn = "1528-7483",
publisher = "American Chemical Society",
number = "8",

}

TY - JOUR

T1 - Inorganic-organic nanocomposite assembly using collagen as a template and sodium tripolyphosphate as a biomimetic analog of matrix phosphoprotein

AU - Dai, Lin

AU - Qi, Yi Pin

AU - Niu, Li Na

AU - Liu, Yan

AU - Pucci, Cesar R.

AU - Looney, Stephen Warwick

AU - Ling, Jun Qi

AU - Pashley, David Henry

AU - Tay, Franklin Chi Meng

PY - 2011/8/3

Y1 - 2011/8/3

N2 - Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nanoprecursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.

AB - Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nanoprecursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.

UR - http://www.scopus.com/inward/record.url?scp=79961138805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961138805&partnerID=8YFLogxK

U2 - 10.1021/cg200663v

DO - 10.1021/cg200663v

M3 - Article

VL - 11

SP - 3504

EP - 3511

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 8

ER -