Insights Into the Molecular Mechanisms of Polycystic Kidney Diseases

Valeriia Y. Vasileva, Regina F. Sultanova, Anastasia V. Sudarikova, Daria V. Ilatovskaya

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Autosomal dominant (AD) and autosomal recessive (AR) polycystic kidney diseases (PKD) are severe multisystem genetic disorders characterized with formation and uncontrolled growth of fluid-filled cysts in the kidney, the spread of which eventually leads to the loss of renal function. Currently, there are no treatments for ARPKD, and tolvaptan is the only FDA-approved drug that alleviates the symptoms of ADPKD. However, tolvaptan has only a modest effect on disease progression, and its long-term use is associated with many side effects. Therefore, there is still a pressing need to better understand the fundamental mechanisms behind PKD development. This review highlights current knowledge about the fundamental aspects of PKD development (with a focus on ADPKD) including the PC1/PC2 pathways and cilia-associated mechanisms, major molecular cascades related to metabolism, mitochondrial bioenergetics, and systemic responses (hormonal status, levels of growth factors, immune system, and microbiome) that affect its progression. In addition, we discuss new information regarding non-pharmacological therapies, such as dietary restrictions, which can potentially alleviate PKD.

Original languageEnglish (US)
Article number693130
JournalFrontiers in Physiology
Volume12
DOIs
StatePublished - Sep 8 2021

Keywords

  • calcium
  • cilia
  • microbiome
  • mitochondria
  • polycystic kidney disease

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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