Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis

Jing Zhao, Jie Chen, Ting Hong Yang, Petter Holme

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Complex chronic diseases are usually not caused by changes in a single causal gene but by an unbalanced regulating network resulting from the dysfunctions of multiple genes or their products. Therefore, network based systems approach can be helpful for the identification of candidate genes related to complex diseases and their relationships. Axial spondyloarthropathy (SpA) is a group of chronic inflammatory joint diseases that mainly affect the spine and the sacroiliac joints. The pathogenesis of SpA remains largely unknown.Results: In this paper, we conducted a network study of the pathogenesis of SpA. We integrated data related to SpA, from the OMIM database, proteomics and microarray experiments of SpA, to prioritize SpA candidate disease genes in the context of human protein interactome. Based on the top ranked SpA related genes, we constructed a SpA specific PPI network, identified potential pathways associated with SpA, and finally sketched an overview of biological processes involved in the development of SpA.Conclusions: The protein-protein interaction (PPI) network and pathways reflect the link between the two pathological processes of SpA, i.e., immune mediated inflammation, as well as imbalanced bone modelling caused new boneformation and bone loss. We found that some known disease causative genes, such as TNFand ILs, play pivotal roles in this interaction.

Original languageEnglish (US)
Article numberS4
JournalBMC Systems Biology
Volume6
Issue numberSUPPL.1
DOIs
StatePublished - Jul 16 2012

Fingerprint

Spondylarthropathies
Pathway
Genes
Gene
Proteins
Protein Interaction Networks
Protein-protein Interaction
Bone
Protein Interaction Maps
Chronic Disease
Inflammation
Spine
Proteomics
Microarrays
Microarray
Genetic Databases
Biological Phenomena
Sacroiliac Joint
Bone and Bones
Protein

ASJC Scopus subject areas

  • Structural Biology
  • Modeling and Simulation
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

Cite this

Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis. / Zhao, Jing; Chen, Jie; Yang, Ting Hong; Holme, Petter.

In: BMC Systems Biology, Vol. 6, No. SUPPL.1, S4, 16.07.2012.

Research output: Contribution to journalArticle

Zhao, Jing ; Chen, Jie ; Yang, Ting Hong ; Holme, Petter. / Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis. In: BMC Systems Biology. 2012 ; Vol. 6, No. SUPPL.1.
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