TY - JOUR
T1 - Insomnia, suicidal ideation, and psychopathology in Chinese patients with chronic schizophrenia
AU - Miller, Brian J.
AU - McCall, William V.
AU - Xia, Lei
AU - Zhang, Yulong
AU - Li, Wenzheng
AU - Yao, Xianhu
AU - Liu, Huanzhong
N1 - Funding Information:
The study was supported by the National Clinical Key Specialty Project Foundation (CN), the Anhui Province Key Scientific and Technological Projects (1804 h08020263), and the Scientific Research Foundation of the Institute for Translational Medicine (2017zhyx17).
Funding Information:
Dr. Miller has nothing to disclose for the present work. In the past 12 months, Dr. Miller received research support from Alkermes, Augusta University , NARSAD, the National Institute of Mental Health , and the Stanley Medical Research Institute ; and Honoraria from Psychiatric Times.
Funding Information:
McCall has received research support from PCORI , Merck Pharmaceuticals, Vistagen, and the MECTA Corporation. He has been a consultant for Anthem Insurance, Jazz, Sage and Janssen Pharmaceuticals. He has been a paid CME speaker for CME Outfitters, and has received royalties from Wolters Kluwer.
Funding Information:
Dr. Liu has nothing to disclose for the present work. In the past 12 months, Dr. Liu received research support from the Central Finance Department and the National Health Commission of China, the Science and Technology Department of Anhui Province, and the Scientific Research Department of Chaohu Hospital of Anhui Medical University .
Funding Information:
The study was supported by the National Clinical Key Specialty Project Foundation (CN) , the Anhui Province Key Scientific and Technological Projects ( 1804h08020263 ), and the Scientific Research Foundation of the Institute for Translational Medicine ( 2017zhyx17 ).
Publisher Copyright:
© 2020 Elsevier Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Objectives: Insomnia occurs frequently in the clinical course of schizophrenia. A growing literature has found associations between insomnia, suicidal ideation, and psychopathology in patients with schizophrenia. We explored these associations in a cross-sectional study of a large sample of patients with chronic schizophrenia in China. We hypothesized that insomnia would be associated with an increased odds of current suicidal ideation and higher current psychopathology scores. Methods: We recruited 328 inpatients with chronic schizophrenia, all of whom were prescribed psychotropics. We investigated relationships between current insomnia, suicidal ideation over the past two weeks, and current psychopathology for subjects using regression models. Results: After controlling for multiple potential confounding factors, current insomnia was an indicator of a significant, 2.5-fold increased odds of suicidal ideation (OR = 2.56, 95% CI 1.10–5.95, p = 0.029). Insomnia was also a significant indicator of lifetime suicide attempt (OR = 1.07) as well as higher Positive and Negative Syndrome Scale total (β = 0.134, p = 0.017), positive (β = 0.154, p = 0.006) and general (β = 0.145, p = 0.010) subscale scores. Conclusion: Insomnia is associated with suicidal ideation, lifetime suicide attempt, and higher psychopathology scores in inpatients with chronic schizophrenia. Formal assessment of insomnia appears relevant to the clinical care of patients with schizophrenia as an indicator of suicidal thinking and behavior, depression, and symptom severity.
AB - Objectives: Insomnia occurs frequently in the clinical course of schizophrenia. A growing literature has found associations between insomnia, suicidal ideation, and psychopathology in patients with schizophrenia. We explored these associations in a cross-sectional study of a large sample of patients with chronic schizophrenia in China. We hypothesized that insomnia would be associated with an increased odds of current suicidal ideation and higher current psychopathology scores. Methods: We recruited 328 inpatients with chronic schizophrenia, all of whom were prescribed psychotropics. We investigated relationships between current insomnia, suicidal ideation over the past two weeks, and current psychopathology for subjects using regression models. Results: After controlling for multiple potential confounding factors, current insomnia was an indicator of a significant, 2.5-fold increased odds of suicidal ideation (OR = 2.56, 95% CI 1.10–5.95, p = 0.029). Insomnia was also a significant indicator of lifetime suicide attempt (OR = 1.07) as well as higher Positive and Negative Syndrome Scale total (β = 0.134, p = 0.017), positive (β = 0.154, p = 0.006) and general (β = 0.145, p = 0.010) subscale scores. Conclusion: Insomnia is associated with suicidal ideation, lifetime suicide attempt, and higher psychopathology scores in inpatients with chronic schizophrenia. Formal assessment of insomnia appears relevant to the clinical care of patients with schizophrenia as an indicator of suicidal thinking and behavior, depression, and symptom severity.
KW - Insomnia
KW - Schizophrenia
KW - Suicidal ideation
KW - Suicide
KW - Suicide attempt
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U2 - 10.1016/j.pnpbp.2020.110202
DO - 10.1016/j.pnpbp.2020.110202
M3 - Article
C2 - 33285266
AN - SCOPUS:85097671506
SN - 0278-5846
VL - 111
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
M1 - 110202
ER -
