Insulin and IGF-1 receptors, nitrotyrosin and cerebral neuronal deficits in two young patients with diabetic ketoacidosis and fatal brain edema

William H. Hoffman, Anuska V. Andjelkovic, Weixian Zhang, Gregory G Passmore, Anders A F Sima

Research output: Contribution to journalArticle

14 Scopus citations


Gray and white matter structural deficits may accompany type 1 diabetes. Earlier experimental studies have demonstrated neuronal deficits associated with impaired neurotrophic support, inflammation and oxidative stress. In this study we demonstrate in two patients with histories of poorly controlled type 1 diabetes and fatal brain edema of ketoacidosis neuronal deficits associated with a decreased presence of insulin and IGF-1 receptors and accumulation of nitrotyrosin in neurons of affected areas and the choroid plexus. The findings add support to the suggested genesis of T1DM encephalopathy due to compromised neurotrophic protection, oxidative stress, inflammation and neuronal deficits, as demonstrated in T1DM encephalopathy in the BB/Wor-rat.

Original languageEnglish (US)
Pages (from-to)168-177
Number of pages10
JournalBrain Research
Publication statusPublished - Jul 9 2010



  • Choroid plexus
  • Diabetic encephalopathy
  • Diabetic ketoacidosis
  • Insulin and IGF-1 receptors
  • Neuronal deficit
  • Oxidative/nitrosative stress
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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